{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:01:48Z","timestamp":1793822508362,"version":"4.6.1"},"reference-count":50,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["08\/14\/44"],"award-info":[{"award-number":["08\/14\/44"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R014019\/1"],"award-info":[{"award-number":["MR\/R014019\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence, prediction and impact of acute kidney injury (AKI) in alcohol\u2010related hepatitis (AH) is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to determine AKI incidence; association with mortality; evaluate serum biomarkers and the modifying effects of prednisolone and pentoxifylline in the largest AH cohort to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants in the Steroids or Pentoxifylline for Alcoholic Hepatitis trial with day zero (D0) creatinine available were included. AKI was defined by modified International Club of Ascites criteria; incident AKI as day 7 (D7) AKI without D0\u2010AKI. Survival was compared by Kaplan\u2013Meier; mortality associations by Cox regression; associations with AKI by binary logistic regression; biomarkers by AUROC analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>D0\u2010AKI was present in 198\/1051 (19%) participants; incident AKI developed in a further 119\/571 (21%) with available data. Participants with D0\u2010AKI had higher 90\u2010day mortality than those without (32% vs. 25%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), as did participants with incident AKI compared to those without D0\u2010AKI or incident AKI (47% vs. 25%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Incident AKI was associated with D90 mortality adjusted for age and discriminant function (AHR 2.15, 1.56\u20132.97, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); D0\u2010AKI was not. Prednisolone therapy reduced incident AKI (AOR 0.55, 0.36\u20130.85, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) but not mortality. D0 bilirubin and IL\u20108 combined, miR\u20106826\u20105p, and miR\u20106811\u20103p predicted incident AKI (AUROCs 0.726, 0.821, 0.770, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Incident AKI is associated with 90\u2010day mortality independent of liver function. Prednisolone therapy was associated with reduced incident AKI. IL\u20108 and several miRNAs are potential biomarkers to predict AKI. Novel therapies to prevent incident AKI should be evaluated in AH to reduce mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17733","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:54:21Z","timestamp":1696240461000},"page":"1217-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["In severe alcohol\u2010related hepatitis, acute kidney injury is prevalent, associated with mortality independent of liver disease severity, and can be predicted using <scp>IL<\/scp>\u20108 and <scp>micro\u2010RNAs<\/scp>"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2745-0282","authenticated-orcid":false,"given":"Luke D.","family":"Tyson","sequence":"first","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"The Liver Unit St Mary's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"The Liver Unit St Mary's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Allison","sequence":"additional","affiliation":[{"name":"Cambridge NIHR Biomedical Research Centre Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Hepatology Royal Derby Hospital  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-8625","authenticated-orcid":false,"given":"James W.","family":"Dear","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7293-2574","authenticated-orcid":false,"given":"Ewan","family":"Forrest","sequence":"additional","affiliation":[{"name":"Department of Hepatology Glasgow Royal Infirmary  Glasgow UK"},{"name":"University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Lord","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-9844","authenticated-orcid":false,"given":"Steven","family":"Masson","sequence":"additional","affiliation":[{"name":"Department of Hepatology Newcastle Freeman Hospital  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Nunes","sequence":"additional","affiliation":[{"name":"Meso Scale Diagnostics  Gaithersburg USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Royal Liverpool University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Ryder","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust and the University of Nottingham Queens Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Hepatology University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Thursz","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"The Liver Unit St Mary's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Vergis","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"The Liver Unit St Mary's Hospital  London UK"},{"name":"GSK  Brentford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1412278"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.018"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2011.09.011"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/LT.25328"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCEH.2014.02.068"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0048580"},{"key":"e_1_2_13_8_1","unstructured":"NCEPOD \u2010 Acute Kidney Injury: Adding Insult to Injury Report.2009Accessed July 4 2022.https:\/\/www.ncepod.org.uk\/2009aki.html"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMRA2215289\/SUPPL_FILE\/NEJMRA2215289_DISCLOSURES.PDF"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.12.008"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","unstructured":"KDIGO.Clinical Practice Guideline for Acute Kidney Injury.https:\/\/doi.org\/10.1038\/kisup.2012.1","DOI":"10.1038\/kisup.2012.1"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2016.05.025"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.AJKD.2020.03.016"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1081\/JDI\u2010100104725"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02510706"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000291649.72238.6D"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/CC7940"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPRENAL.00005.2015"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/KI.2009.142"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00123"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/JCP.27203"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106215\u201014\u2010262"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102014\u2010308874"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2013.04.036"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2013.03.039"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2013.08.051"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102011\u2010301255"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/LIV.12852"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2016.02.042"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2022.03.025\/ATTACHMENT\/3C5DA755\u2010C732\u20104CCC\u2010B4F2\u2010D50BEE0EB403\/MMC1.PDF"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(78)90401\u20108"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/JHEP.2001.22172"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUT.2004.050781"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2016.12.019"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2021436"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014080840"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.637753"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2014.03.014"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12072\u2010014\u20109581\u20101\/FIGURES\/4"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/APT.12279"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/LIV.12786"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3350\/CMH.2020.0234"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2015.10.018"},{"key":"e_1_2_13_45_1","doi-asserted-by":"crossref","unstructured":"WuZ HouM PengH et al.Plasma exosome\u2010derived microRNAs panel: a novel predictor of liver injury in cholecystitis patients.2022https:\/\/doi.org\/10.21203\/RS.3.RS\u20101945357\/V1","DOI":"10.21203\/rs.3.rs-1945357\/v1"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0118220"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/S41544\u2010019\u20100025\u2010X\/TABLES\/1"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS23031664\/S1"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016090974\/\u2010\/DCSUPPLEMENTAL"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102021\u2010BSG.44"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20108278(22)00628\u20106"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T19:13:40Z","timestamp":1700680420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":50,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/apt.17733"],"URL":"https:\/\/doi.org\/10.1111\/apt.17733","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"2023-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}