{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:11:58Z","timestamp":1787991118414,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with chronic hepatitis B (CHB) who switch from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) show changes in lipid profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate how these changes affect cardiovascular risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This pooled analysis, based on two large prospective studies, evaluated fasting lipid profiles of patients with CHB who were treated with TAF 25\u2009mg\/day or TDF 300\u2009mg\/day for 96\u2009weeks. Patients who fulfilled the American College of Cardiology criteria (age 40\u201379\u2009years, high\u2010density lipoprotein [HDL] 20\u2013100\u2009mg\/dL, total cholesterol [TC] 130\u2013320\u2009mg\/dL and systolic blood pressure 90\u2013200\u2009mmHg) required to assess 10\u2010year atherosclerotic cardiovascular disease (ASCVD) risk with baseline lipid data and at least one post\u2010baseline measurement were included in the ASCVD\u2010risk population. The 10\u2010year ASCVD risk was calculated for patients in this population, and changes from baseline to Week 96 were assessed using intermediate\u2010 (\u22657.5%) and high\u2010risk (\u226520%) cut\u2010offs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1632 patients, 620 (38%) met the criteria for the ASCVD\u2010risk population. At Week 96, fasting levels of all lipids, except TC:HDL ratio, were lower with TDF than TAF. No significant increase was observed in overall ASCVD risk or in any ASCVD\u2010risk categories during the 96\u2010week treatment period compared with baseline. A similar proportion of patients in the TAF and TDF treatment groups (1.3% and 2.3%, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.34) reported cardiovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite on\u2010treatment differences in lipid profiles with TAF and TDF, predicted cardiovascular risk and clinical events were similar for both groups after 96 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17764","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T08:58:44Z","timestamp":1698742724000},"page":"217-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Atherosclerotic cardiovascular disease risk profile of patients with chronic hepatitis B treated with tenofovir alafenamide or tenofovir disoproxil fumarate for 96\u2009weeks"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-8800","authenticated-orcid":false,"given":"Scott K.","family":"Fung","sequence":"first","affiliation":[{"name":"Department of Medicine University of Toronto  Ontario Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-6688","authenticated-orcid":false,"given":"Calvin Q.","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, NYU Langone Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Lai\u2010Hung","family":"Wong","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre (MDAC), Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9012-313X","authenticated-orcid":false,"given":"Wai\u2010Kay","family":"Seto","sequence":"additional","affiliation":[{"name":"Department of Medicine and State Key Laboratory of Liver Research The University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-4624","authenticated-orcid":false,"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Ditmanson Medical Foundation Chia\u2010Yi Christian Hospital  Chiayi City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-8700","authenticated-orcid":false,"given":"Hie\u2010Won L.","family":"Hann","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Sidney Kimmel Medical College, Thomas Jefferson University Hospital  Pennsylvania Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej S.","family":"Jablkowski","sequence":"additional","affiliation":[{"name":"Department of Infectious and Liver Diseases Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-7773","authenticated-orcid":false,"given":"Yoon Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Yurdaydin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ankara  Ankara Turkey"},{"name":"Department of Gastroenterology and Hepatology Ko\u00e7 University Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-6086","authenticated-orcid":false,"given":"Cheng\u2010Yuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Digestive Medicine China Medical University Hospital, China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"T Nguyen Research and Education, Inc.  California San Diego USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yatsuhashi","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Nagasaki Medical Center  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Gilead Sciences  California Foster City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-5878","authenticated-orcid":false,"given":"Leland J.","family":"Yee","sequence":"additional","affiliation":[{"name":"Gilead Sciences  California Foster City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Abramov","sequence":"additional","affiliation":[{"name":"Gilead Sciences  California Foster City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Gilead Sciences  California Foster City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzhamal","family":"Abdurakhmanov","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-577X","authenticated-orcid":false,"given":"Young\u2010Suk","family":"Lim","sequence":"additional","affiliation":[{"name":"Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-3078","authenticated-orcid":false,"given":"Maria","family":"Buti","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Universitari Valle Hebron Liver Unit Hospital Universitari Valle Hebron  Barcelona Spain"},{"name":"IBER\u2010EHD del Institute Carlos III  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Hepatitis B. Accessed December 20 2021.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010b"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1264932"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00128\u201015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(16)30107\u20108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30421\u20102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.04.045"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.035"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(16)30024\u20103"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.039"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ296"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S274307"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2019.0236"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12984"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000625"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.12.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i3.282"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2007.03538.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i1.155"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12658"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00145"},{"key":"e_1_2_8_26_1","unstructured":"ACC\/AHA Pooled Cohort Equations. Accessed September 27 2022.http:\/\/tools.acc.org\/ASCVD\u2010Risk\u2010Estimator\/"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz472"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002350"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010021\u201006479\u20109"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13161"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.005"},{"key":"e_1_2_8_32_1","unstructured":"Cardiovascular diseases (CVDs). Accessed September 27 2022.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cardiovascular\u2010diseases\u2010(cvds)"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz414"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(20)30036\u20109"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.04.059"},{"key":"e_1_2_8_36_1","first-page":"757","article-title":"Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention","volume":"5","author":"Mill\u00e1n J","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010019\u20101228\u20107"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2004.01341.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/lipd.12337"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2022.06.003"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319862401"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010020\u201001750\u20103"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60595\u20104"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12432"},{"key":"e_1_2_8_45_1","unstructured":"Liverpool HEP Interactions. Accessed November 1 2020.https:\/\/www.hep\u2010druginteractions.org\/checker"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.0917"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2020.19656"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002541"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011874"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039049\u2010w"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T06:22:42Z","timestamp":1717482162000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/apt.17764"],"URL":"https:\/\/doi.org\/10.1111\/apt.17764","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]},"assertion":[{"value":"2023-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}