{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:37:19Z","timestamp":1784291839726,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on patients switched to tenofovir alafenamide (TAF) from nucleos(t)ide analogues (NUCs) other than tenofovir disoproxil fumarate are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the treatment and renal\/bone safety outcomes following the switch to TAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled adult patients with chronic hepatitis B (CHB) who switched from any NUC to TAF at 14 centres in Japan, Korea, Taiwan and the U.S. Study outcomes were viral suppression (VR; HBV DNA\u2009&lt;\u200920\u2009IU\/mL), biochemical response (BR; alanine aminotransferase normalisation), and changes in estimated glomerular filtration rate (eGFR) and T\u2010scores (L\u2010spine) by bone absorptiometry by 24\u2009months after switch to TAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 270 eligible patients. Mean age was 58.1; 58.2% were male; 12.2% had cirrhosis and 73.3% previously received entecavir monotherapy. VR rate increased significantly from 95.2% to 98.8% by 24\u2009months after the switch to TAF (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). Between the switch and 24\u2009months later, the mean spine T\u2010score improved significantly from \u22121.43\u2009\u00b1\u20091.36 to \u22121.17\u2009\u00b1\u20091.38 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), while there was no significant change in mean eGFR (88.4\u2009\u00b1\u200916.9\u201389.5\u2009\u00b1\u200916.3\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.13). On multivariable analysis adjusted for age, sex, baseline spine T\u2010score and prior TDF or adefovir dipivoxil use, male sex was significantly associated with lower risk of worsening spine T\u2010score (odds ratio: 0.29, <jats:italic>p<\/jats:italic>\u2009=\u20090.020), while age was significantly associated with a higher risk of worsening chronic kidney disease stage (OR: 1.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 24\u2009months after the switch to TAF, VR rates and spine bone density improved significantly while renal function remained stable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17785","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T10:30:52Z","timestamp":1698316252000},"page":"239-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Increased spine bone density in patients with chronic hepatitis B switched to tenofovir alafenamide: A prospective, multinational study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-3967","authenticated-orcid":false,"given":"Eiichi","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University, College of Medicine  Seoul South Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology, Hanyang University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Chun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine E\u2010Da Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-048X","authenticated-orcid":false,"given":"Eileen L.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University, College of Medicine  Seoul South Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology, Hanyang University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7419-5259","authenticated-orcid":false,"given":"Sang Bong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nowon Eulji Medical Center Eulji University College of Medicine  Seoul South 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