{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:51:46Z","timestamp":1785232306537,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gut\u2010directed hypnotherapy is effective for patients with irritable bowel syndrome (IBS). Despite its considerable evidence base, gut\u2010directed hypnotherapy is not widely available and remains a limited resource. This emphasises the need to select patients who are most likely to benefit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine whether baseline patient characteristics were predictive of response to gut\u2010directed hypnotherapy in patients with IBS<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a secondary analysis of outcomes of 448 patients with refractory Rome III IBS who participated in a randomised study confirming non\u2010inferiority of 6 compared to 12 sessions of gut\u2010directed hypnotherapy. We compared baseline patient characteristics, including age, sex, IBS subtype, quality of life and IBS\u2010Symptom Severity Scale (IBS\u2010SSS), non\u2010colonic symptom score and Hospital Anxiety and Depression (HAD) score between responders and non\u2010responders. We defined response as \u226550\u2010point decrease in IBS\u2010SSS or\u2009\u226530% reduction in pain severity scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 76.3% achieved \u226550\u2010point decrease in IBS\u2010SSS. Responders had a higher baseline non\u2010colonic symptom score (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). Those who achieved \u226530% improvement in abdominal pain scores (59.8%) had higher baseline IBS\u2010SSS (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), and lower baseline HAD\u2010depression score (<jats:italic>p<\/jats:italic>\u2009=\u20090.012). Fifty\u2010four patients (12%) dropped out of gut\u2010directed hypnotherapy. Compared to completers, dropouts had higher baseline HAD\u2010anxiety score (<jats:italic>p<\/jats:italic>\u2009=\u20090.034).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that patients with a higher burden of gastrointestinal and extraintestinal symptoms are most likely to benefit from gut\u2010specific behavioural intervention for refractory IBS. Clinical assessment of gastrointestinal, somatic and psychological symptom profiles may play a role in selecting patients for gut\u2010directed hypnotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17790","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T07:26:13Z","timestamp":1699255573000},"page":"269-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical trial: predictive factors for response to gut\u2010directed hypnotherapy for refractory irritable bowel syndrome, a <i>post hoc<\/i> analysis"],"prefix":"10.1111","volume":"59","author":[{"given":"Jade","family":"Devenney","sequence":"first","affiliation":[{"name":"Neurogastroenterology Unit, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed S.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Whorwell","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-0616","authenticated-orcid":false,"given":"Dipesh H.","family":"Vasant","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16939"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13573"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.201"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200220070-00003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0000000000000530"},{"issue":"2","key":"e_1_2_9_9_1","first-page":"S3","article-title":"Impact of irritable bowel syndrome: prevalence and effect on health\u2010related quality of life","volume":"3","author":"El\u2010Serag HB","year":"2003","journal-title":"Rev Gastroenterol Disord"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16484"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200119060-00003"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"A33","article-title":"OC\u2010066 economic and quality\u2010of\u2010life burden of moderate\u2010to\u2010severe irritable bowel syndrome with constipation (IBS\u2010C) in the UK: the ibis\u2010c study","volume":"64","author":"Yiannakou Y","year":"2015","journal-title":"Gut"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17132"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12938"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.t01-1-01736.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00262.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321191"},{"key":"e_1_2_9_18_1","unstructured":"NICE.Irritable bowel syndrome in adults: diagnosis and management clinical guideline [CG61]. 2008.https:\/\/www.nice.org.uk\/Guidance\/CG61."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324598"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.031"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30310-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207144.2012.700620"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90013-5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.19"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.1.37"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13145"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2020-101679"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.02.058"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12770"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1623"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.658858"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003478"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16934"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207144.2019.1553766"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207144.2023.2185527"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14554"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2022-001039"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14533"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207140802665401"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-10-12"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-10-75"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04143.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05615.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6516.344"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_9_48_1","first-page":"32124","volume-title":"Guidance for industry on irritable bowel syndrome\u2014clinical evaluation of drugs for treatment availability","author":"Administration FD","year":"2012"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221114558"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14347"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.015"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0502-z"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00072-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000975"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.02.016"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16322"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6708.1138"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.7.784"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04402.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T06:23:19Z","timestamp":1717482199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,5]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/apt.17790"],"URL":"https:\/\/doi.org\/10.1111\/apt.17790","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,5]]},"assertion":[{"value":"2023-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}