{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:12:33Z","timestamp":1782234753042,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005347","name":"American Association for the Study of Liver Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","award":["I01HX003062"],"award-info":[{"award-number":["I01HX003062"]}],"id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether the risk of hepatocellular carcinoma (HCC) decreases over time following hepatitis C virus (HCV) eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if patients who have accrued longer time since sustained virologic response (SVR) have a lower risk of HCC than those with less time since SVR<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of all HCV\u2010infected Veterans Affairs patients who achieved SVR before 1 January 2018 and remained alive without a diagnosis of HCC as of 1 January 2019 (<jats:italic>n<\/jats:italic>\u2009=\u200975,965). We ascertained their baseline characteristics as of 1 January 2019 (time zero), including time accrued since SVR and followed them for the subsequent 12\u2009months for incident HCC. We used multivariable Cox proportional hazards regression to determine the association between time since SVR and HCC risk after adjusting for age, race\/ethnicity, sex, diabetes, hypertension, body mass index, alcohol use, Charlson Comorbidity Index, Fibrosis\u20104 score, HCV genotype, hepatitis B virus co\u2010infection and HIV co\u2010infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>96.0% were male; mean age was 64.6\u2009 years. Among those with cirrhosis (<jats:italic>n<\/jats:italic>\u2009=\u200919,678, 25.9%), compared to patients who had accrued only \u22651 to 2\u2009years since SVR (HCC incidence 2.71\/100 person\u2010years), those who had accrued &gt;2 to 4\u2009years (2.11\/100 person\u2010years, aHR 0.80, 95% CI 0.63\u20131.01) and &gt;4 to 6\u2009years (1.65\/100 person\u2010years, aHR 0.61, 95% CI 0.41\u20130.90) had progressively lower HCC risk. However, HCC risk appeared to plateau for those with &gt;6\u2009years since SVR (1.68\/100 person\u2010years, aHR 0.70, 95% CI 0.46\u20131.07). Among those without cirrhosis, HCC risk was 0.23\u20130.27\/100 person\u2010years without a significant association between time since SVR and HCC risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with cirrhosis and cured HCV infection, HCC risk declined progressively up to 6\u2009years post\u2010SVR\u2014although it remained well above thresholds that warrant screening. This suggests that time since SVR can inform HCC surveillance strategies in patients with cured HCV infection and can be incorporated into HCC risk prediction models.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17802","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T10:38:50Z","timestamp":1699871930000},"page":"361-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hepatocellular carcinoma risk decreases as time accrues following hepatitis C virus eradication"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-6077","authenticated-orcid":false,"given":"Philip","family":"Vutien","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington  Seattle Washington USA"},{"name":"Division of Gastroenterology Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-0580","authenticated-orcid":false,"given":"Nicole J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington  Seattle Washington USA"},{"name":"Division of Gastroenterology Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-2062","authenticated-orcid":false,"given":"Andrew M.","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Lineberger Comprehensive Cancer Center The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Hospital and Specialty Medicine Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"},{"name":"Division of General Internal Medicine University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Berry","sequence":"additional","affiliation":[{"name":"Health Service Research and Development Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela K.","family":"Green","sequence":"additional","affiliation":[{"name":"Health Service Research and Development Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George N.","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington  Seattle Washington USA"},{"name":"Division of Gastroenterology Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"},{"name":"Health Service Research and Development Veterans Affairs Puget Sound Health Care System  Seattle Washington 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