{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:38:58Z","timestamp":1791549538114,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012921","name":"Royal College of Surgeons in Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease affecting approximately 25% of adults in the western world. Intragastric balloon (IGB) is an endoscopic bariatric therapy \u2010a therapeutic endoscopic tool that has shown promise in inducing weight loss. Its role in the treatment of NAFLD is yet to be established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of IGB as a treatment option in NAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE (PubMed) and EMBASE from inception to September 2022. We included studies evaluating the impact of IGB on obesity with the assessment of one or more liver\u2010related outcomes and studies primarily evaluating the impact of IGB on NAFLD. We included comparative and non\u2010comparative studies; primary outcomes were liver\u2010related NAFLD surrogates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 19 studies with 911 patients. IGB demonstrated an effect on NAFLD parameters including NAFLD activity score (NAS): mean difference (MD): \u22123.0 [95% CI: \u22122.41 to \u22123.59], ALT: MD: \u221210.40\u2009U\/L [95% CI: \u22127.31 to \u221213.49], liver volume: MD \u2010397.9 [95% CI: \u2212212.78 to 1008.58] and liver steatosis: MD: \u221237.76\u2009dB\/m [95% CI: \u221221.59 to \u221253.92]. There were significant reductions in non\u2010liver\u2010related outcomes of body weight, BMI, glycated haemoglobin and HOMA\u2010IR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intragastric balloons may play an important role in addressing the treatment gap in NAFLD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17805","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T18:08:53Z","timestamp":1700590133000},"page":"8-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Meta\u2010analysis: Impact of intragastric balloon therapy on NAFLD\u2010related parameters in patients with 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