{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:42:28Z","timestamp":1772505748630,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric and duodenal ulcerations are common during multiple\u2010dosing aspirin treatment, such as for prevention of cardiovascular disease. On capsule endoscopy, oral administration of the bacterial strain <jats:italic>Bifidobacterium breve<\/jats:italic> Bif195 (DSM 33360) reduced the risk of aspirin\u2010induced small intestinal damage, without affecting cyclo\u2010oxygenase\u20102 (COX\u20102) inhibition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate endoscopically the effect of Bif195 on aspirin\u2010induced stomach and duodenal mucosal damage<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five healthy volunteers underwent two intervention periods in a randomised, double\u2010blind, placebo\u2010controlled crossover design including four gastroduodenoscopies and 6\u2009weeks washout. Each intervention was a 4\u2010week oral co\u2010treatment of aspirin 300\u2009mg daily and Bif195 (\u226510<jats:sup>11<\/jats:sup> colony\u2010forming units daily) or placebo. Primary endpoint was change in Lanza score \u2010 ranging from 0 (normal mucosa) to 4 (&gt;10 erosions or ulcer).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 25 participants (56% females); age 27.3 (\u00b14.8) years; BMI 23.2 (\u00b13.4)\u2009kg\/m<jats:sup>2<\/jats:sup>, completed the trial exhibiting significant increases in Lanza scores during placebo treatment as compared to baseline. Bif195 reduced gastric Lanza score with an odds ratio of 7.2 (95% confidence interval 1.72\u201330.08, <jats:italic>p<\/jats:italic>\u2009=\u20090.009) compared to placebo with no related adverse events. There were no significant changes in Lanza scores in the duodenum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bif195 reduces aspirin\u2010induced gastric mucosal damage and may serve as a safe supplement during multiple\u2010dosing aspirin treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17817","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T04:04:02Z","timestamp":1701403442000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>Bifidobacterium breve<\/i> Bif195 ameliorates aspirin\u2010induced gastric mucosal damage: A randomised, double blind, placebo\u2010controlled crossover trial"],"prefix":"10.1111","volume":"59","author":[{"given":"Nina","family":"L\u00f8n","sequence":"first","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-2741","authenticated-orcid":false,"given":"Sara","family":"Engel","sequence":"additional","affiliation":[{"name":"Chr. Hansen A\/S, Human Health, Scientific Affairs  H\u00f8rsholm Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1657-1659","authenticated-orcid":false,"given":"Anders","family":"Damholt","sequence":"additional","affiliation":[{"name":"Chr. Hansen A\/S, Human Health, Scientific Affairs  H\u00f8rsholm Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brynjulf","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Chr. Hansen A\/S, Human Health, Scientific Affairs  H\u00f8rsholm Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B.","family":"Haaber","sequence":"additional","affiliation":[{"name":"Mavespecialisten  Charlottenlund Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-6063","authenticated-orcid":false,"given":"Anja","family":"Wellejus","sequence":"additional","affiliation":[{"name":"Chr. 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