{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:43:54Z","timestamp":1791319434846,"version":"4.3.1"},"reference-count":266,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The current obesity pandemic has given rise to associated comorbidities and complications, including type 2 diabetes and metabolic dysfunction\u2010associated steatotic liver disease (MASLD). During the last decade, certain glucagon\u2010like peptide 1 receptor agonists (GLP\u20101RA), originally developed as antihyperglycemic drugs, also demonstrated efficacy for weight loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To review shared pathophysiologic features of common metabolic diseases and compare therapeutic strategies to reduce body weight and related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an extensive literature research to describe the effects of lifestyle modification, first\u2010generation anti\u2010obesity drugs, and GLP\u20101RA on weight loss in humans with obesity, type 2 diabetes and MASLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Until recently, treatment of obesity has been limited to lifestyle modification, which offer moderate degree and sustainability of weight loss. The few approved first\u2010generation anti\u2010obesity drugs are either limited to short term use or to certain forms of obesity. Some GLP\u20101RA significantly decrease caloric intake and body weight. Liraglutide and semaglutide have therefore been approved for treating people with obesity. They also lead to a reduction of hepatic fat content and inflammation in people with biopsy\u2010confirmed MASLD. Possible limitations comprise adverse effects, treatment adherence and persistence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Certain GLP\u20101RA are superior to lifestyle modification and first\u2010generation anti\u2010obesity drugs in inducing weight loss. They have therefore markedly changed the portfolio of obesity treatment with additional beneficial effects on steatotic liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17848","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T11:57:01Z","timestamp":1717070221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Role of lifestyle and glucagon\u2010like peptide\u20101 receptor agonists for weight loss in obesity, type 2 diabetes and steatotic liver diseases"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7817-803X","authenticated-orcid":false,"given":"Anna","family":"Giannakogeorgou","sequence":"first","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center Leibniz Institute for Diabetes Research at Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), Partner D\u00fcsseldorf  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-6382","authenticated-orcid":false,"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center Leibniz Institute for Diabetes Research at Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), Partner D\u00fcsseldorf  Neuherberg Germany"},{"name":"Division of Endocrinology and Diabetology Medical Faculty and University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Obesity Federation.World obesity atlas.2023. Marchhttps:\/\/data.worldobesity.org\/publications\/?cat=19"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706978"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154299"},{"key":"e_1_2_6_5_1","volume-title":"IDF Diabetes Atlas 10th Edition Scientific Committee. IDF diabetes atlas. 10th ed. International Diabetes Federation","author":"Magliano DJ","year":"2021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5953"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(22)00165\u20100"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330110"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2023.01.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000448\u2010y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.075"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100104\u20109"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141828"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092358"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101797\u20108"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154892"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.017"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.06.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010002\u20101009\u20100"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010003\u20101129\u20101"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28985"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010071715\u2010050656"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20101758"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00379"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.01.024"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.005"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010023\u201000898\u20101"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11\u20100390"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.001"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100061\u20103"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2011.11.011"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11061595"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa004"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(17)30292\u20109"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010016\u20100374\u20109"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010021\u201005625\u2010x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010019\u20100310\u20107"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.08.010"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u2010S002"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi20\u20100001"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20101116\u20109"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30187\u20101"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.051"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.08.045"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000323"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(22)00338\u20107"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.02.005"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263931"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2002.tb04294.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214655"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030699"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23023"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4851671"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13727"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14709"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010020\u201001568\u20108"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4743"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac066"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14204391"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14224870"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191610429"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123774"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387\u2010020\u201000142\u2010z"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072005"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14837"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuab040"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093193"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.05.011"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013149"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12816"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15096"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.06.037"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1081096"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101723751"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa926"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000212"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100256"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47763-8"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.709683"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010329998"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.018"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109003"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.39558"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010019\u20101132\u20108"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430\u2010020\u201000821\u20101"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156157"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12911"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13218"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.921085"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13137"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201015770\u2010x"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010046252"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12719"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091729"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2021.113453"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001135"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056756"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212914"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(16)30162\u20100"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15\u20100575"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010022\u201006011\u20101"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010015\u20101691\u2010x"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00634\u20107"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.006"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19569"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017\u201000253"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101882"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010023\u201001284\u20107"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020212"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.04.004"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.145"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010021\u201000337\u20108"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)60888\u20104"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20309"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23152"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R501"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14\u20100930"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010018\u20100946\u2010y"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899\u20109007(00)00452\u20104"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01640\u20108"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.124"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S95299"},{"key":"e_1_2_6_125_1","volume-title":"LiverTox: clinical and research information on drug\u2010induced liver injury [Internet]","year":"2012"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010013\u20100074\u20107"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18\u2010296\u2010LB"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10\u20101791"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12980"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(20)30364\u20108"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1177\/87551225221116010"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa023"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104342\u2010z"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105782"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115669"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.09.018"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032227"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2023.06.003"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520902845268"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2012.18"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20100641"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010019\u20101057\u20100"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101122"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15\u20100355"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22066"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23331"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1696"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14670"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010022\u201000535\u20106"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4573"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14555"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2022.102657"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97233"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00260"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.09.010"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010023\u201005956\u2010x"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13129"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac018"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101102"},{"key":"e_1_2_6_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101351"},{"key":"e_1_2_6_162_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011\u20101443"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.09.010"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.03.009"},{"key":"e_1_2_6_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13827"},{"key":"e_1_2_6_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.07.008"},{"key":"e_1_2_6_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101352"},{"key":"e_1_2_6_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010022\u201000606\u20109"},{"key":"e_1_2_6_169_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00413.2013"},{"key":"e_1_2_6_170_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15\u20102706"},{"key":"e_1_2_6_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13120"},{"key":"e_1_2_6_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14373"},{"key":"e_1_2_6_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15611"},{"key":"e_1_2_6_174_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018\u201000004"},{"key":"e_1_2_6_175_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.59965"},{"key":"e_1_2_6_176_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00280.2019"},{"key":"e_1_2_6_177_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01168"},{"key":"e_1_2_6_178_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010023\u201005966\u20109"},{"key":"e_1_2_6_179_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010012\u20102738\u20103"},{"key":"e_1_2_6_180_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901118"},{"key":"e_1_2_6_181_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612917"},{"key":"e_1_2_6_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2660"},{"key":"e_1_2_6_183_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_2_6_184_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20102677"},{"key":"e_1_2_6_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13487"},{"key":"e_1_2_6_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31149\u20103"},{"key":"e_1_2_6_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2670"},{"key":"e_1_2_6_188_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15\u20100165"},{"key":"e_1_2_6_189_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12624"},{"key":"e_1_2_6_190_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3224"},{"key":"e_1_2_6_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12382"},{"key":"e_1_2_6_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(17)30013\u2010X"},{"key":"e_1_2_6_193_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.14752"},{"key":"e_1_2_6_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.06.013"},{"key":"e_1_2_6_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13764"},{"key":"e_1_2_6_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(20)30075\u20109"},{"key":"e_1_2_6_197_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20102656"},{"key":"e_1_2_6_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01302\u20108"},{"key":"e_1_2_6_199_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101326.2012.01673.x"},{"key":"e_1_2_6_200_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac112"},{"key":"e_1_2_6_201_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010022\u201001360\u20107"},{"key":"e_1_2_6_202_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12030454"},{"key":"e_1_2_6_203_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278685"},{"key":"e_1_2_6_204_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14225"},{"key":"e_1_2_6_205_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12680"},{"key":"e_1_2_6_206_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010021\u201005392\u20109"},{"key":"e_1_2_6_207_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3292"},{"key":"e_1_2_6_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(17)30285\u20106"},{"key":"e_1_2_6_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u201005021\u20106"},{"key":"e_1_2_6_210_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010016\u20104100\u20107"},{"key":"e_1_2_6_211_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016\u20102775"},{"key":"e_1_2_6_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00803\u2010X"},{"key":"e_1_2_6_213_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_6_214_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1132004"},{"key":"e_1_2_6_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31773\u20102"},{"key":"e_1_2_6_216_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010020\u201000796\u2010z"},{"key":"e_1_2_6_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2019.101117"},{"key":"e_1_2_6_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14863"},{"key":"e_1_2_6_219_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13435"},{"key":"e_1_2_6_220_1","doi-asserted-by":"crossref","unstructured":"ArmstrongMJ OkanoueT PalleMS SejlingAS RodenM.Similar weight loss with Semaglutide regardless of diabetes and cardiometabolic risk parameters in individuals with non\u2010alcoholic fatty liver disease: post hoc analysis of three randomized controlled trials. Published Online Abstract Only.2023;78:S827.","DOI":"10.1016\/S0168-8278(23)02295-X"},{"key":"e_1_2_6_221_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_2_6_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(23)00068\u20107"},{"key":"e_1_2_6_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01182\u20100"},{"key":"e_1_2_6_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01185\u20106"},{"key":"e_1_2_6_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01127\u20103"},{"key":"e_1_2_6_226_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_6_227_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12780"},{"key":"e_1_2_6_228_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20102761"},{"key":"e_1_2_6_229_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12305"},{"key":"e_1_2_6_230_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010020\u201005265\u20107"},{"key":"e_1_2_6_231_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13649"},{"key":"e_1_2_6_232_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20102316"},{"key":"e_1_2_6_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32261\u2010X"},{"key":"e_1_2_6_234_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509225"},{"key":"e_1_2_6_235_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13824"},{"key":"e_1_2_6_236_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14020"},{"key":"e_1_2_6_237_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108269"},{"key":"e_1_2_6_238_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302392"},{"key":"e_1_2_6_239_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15150"},{"key":"e_1_2_6_240_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.14493"},{"key":"e_1_2_6_241_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19574"},{"key":"e_1_2_6_242_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22\u20101148"},{"key":"e_1_2_6_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108255"},{"key":"e_1_2_6_244_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261\u2010021\u201001110\u2010w"},{"key":"e_1_2_6_245_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11010136"},{"key":"e_1_2_6_246_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12838"},{"key":"e_1_2_6_247_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399816666200705210006"},{"key":"e_1_2_6_248_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.33457"},{"key":"e_1_2_6_249_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010023\u201001382\u20109"},{"key":"e_1_2_6_250_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.16290"},{"key":"e_1_2_6_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101090"},{"key":"e_1_2_6_252_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010022\u201000783\u20103"},{"key":"e_1_2_6_253_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20101892"},{"key":"e_1_2_6_254_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16126"},{"key":"e_1_2_6_255_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15148"},{"key":"e_1_2_6_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01200\u2010X"},{"key":"e_1_2_6_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031328\u2010x"},{"key":"e_1_2_6_258_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14948"},{"key":"e_1_2_6_259_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20102151"},{"key":"e_1_2_6_260_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2301972"},{"key":"e_1_2_6_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01053\u2010X"},{"key":"e_1_2_6_262_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12433"},{"key":"e_1_2_6_263_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12432"},{"key":"e_1_2_6_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.05.013"},{"key":"e_1_2_6_265_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010023\u201005962\u2010z"},{"key":"e_1_2_6_266_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13872"},{"key":"e_1_2_6_267_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16608"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T19:05:49Z","timestamp":1717787149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":266,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/apt.17848"],"URL":"https:\/\/doi.org\/10.1111\/apt.17848","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]},"assertion":[{"value":"2023-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}