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It is associated with bothersome symptoms, increased healthcare costs, disgruntled caregivers and impaired health\u2010related quality of life. Paediatric FC is a clinical diagnosis based on the Rome IV criteria and is characterised by decreased bowel movement frequency and\/or hard, painful stools and can be complicated by retentive faecal incontinence. Stressful life events, difficult temperaments and emotional and behavioural challenges have been implicated in increasing risk of developing paediatric FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To provide current concepts in pathophysiology, evaluation and management of paediatric FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed pertinent literature after a comprehensive search utilising PubMed with keywords FC, chronic childhood constipation and paediatric FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the last decade, advances in our understanding of paediatric FC have changed the landscape of diagnosing and treating this disorder. Although polyethylene glycol is the first\u2010line treatment for maintenance of FC, the armamentarium of therapeutics has expanded including the first Food and Drug Administration\u2010 agent, linaclotide, for children 6\u201317\u2009years of age in conjunction with more emphasis on behavioural and physical therapy interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment approach to paediatric FC should be individualised and integrated focusing on parental education, lifestyle and behavioural modifications, and pharmacological therapy to maximise therapeutic success. This review highlights advances in pathophysiology, diagnosis and treatment of FC in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17852","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T10:33:22Z","timestamp":1719311602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Functional Constipation: Pathophysiology, evaluation, and management"],"prefix":"10.1111","volume":"60","author":[{"given":"Alexandra","family":"Kilgore","sequence":"first","affiliation":[{"name":"Digestive Health Institute, Children's Hospital Colorado, Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-0382","authenticated-orcid":false,"given":"Julie","family":"Khlevner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, 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