{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:12:57Z","timestamp":1789096377895,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric cancer ranks fourth in terms of global cancer\u2010related deaths. Timely identification of high\u2010risk populations is crucial to reduce mortality. Although a family history of gastric cancer increases risk, European and British guidelines report weak recommendations and low\u2010quality evidence about the management of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To quantify the association in case\u2013control studies of patients with gastric cancer with first\u2010degree relatives with gastric cancer compared to those who do not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review and meta\u2010analysis of case\u2013control studies up to November 2023. Data extraction was performed independently by two reviewers. The heterogeneity of effects across studies was quantified by\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      . We calculated odds ratios (OR) with 95% confidence intervals (CI) using random effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 30 studies in the systematic review. In all studies, a first\u2010degree family history of gastric cancer represented a risk factor for gastric cancer. We included 21 studies on the risk of gastric cancer. There was a significantly increased association between gastric cancer and having first\u2010degree relative(s) with gastric cancer, but with significant heterogeneity among studies (OR\u2009=\u20092.92; 95% CI 2.402\u20133.552;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200981.85%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis highlights the relevance of patients' family history of gastric cancer and the importance of this risk factor for the early detection of neoplastic conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17872","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:35:00Z","timestamp":1704857700000},"page":"606-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Systematic review and meta\u2010analysis: Risk of gastric cancer in patients with first\u2010degree relatives with gastric cancer"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1915-8472","authenticated-orcid":false,"given":"Irene","family":"Ligato","sequence":"first","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8178-2273","authenticated-orcid":false,"given":"Ludovica","family":"Dottori","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Sbarigia","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9070-7733","authenticated-orcid":false,"given":"Emanuele","family":"Dilaghi","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-5957","authenticated-orcid":false,"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-8639","authenticated-orcid":false,"given":"Edith","family":"Lahner","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-5048","authenticated-orcid":false,"given":"Gianluca","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.17849\/insm\u201048\u20101\u20101\u201019.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyy077"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13704"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605380"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010318126"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i13.2435"},{"issue":"12","key":"e_1_2_8_10_1","first-page":"2384","article-title":"Which individuals with positive family history of gastric cancer urgently need intensive screening and eradication of Helicobacter pylori? 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