{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:02:23Z","timestamp":1791864143277,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Noninvasive tests (NITs) have been proposed as an alternative to liver biopsy for diagnosing liver cirrhosis. The evidence of NIT performance in patients with chronic hepatitis D (CHD) is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the diagnostic performance of liver stiffness measurement (LSM) and other NITs in CHD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the diagnostic performance of LSM by transient elastography for the detection of liver cirrhosis in a retrospective, multicentre cohort of 144 CHD patients with paired (\u00b16\u2009months) LSM and liver biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cirrhosis was diagnosed histologically in 22 patients (15.3%). Mean LSM was significantly higher in patients with cirrhosis compared to those without fibrosis (23.4 vs 10.2\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) or with intermediate fibrosis (23.4 vs 13.5\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In the detection of liver cirrhosis, LSM was superior to other NITs (AUROCs: 0.89 [LSM], 0.87 [D4FS], 0.74 [APRI], 0.73 [FIB\u20104], and 0.69 [AAR]). The optimal cut\u2010off for identifying patients with liver cirrhosis was \u226515.2\u2009kPa (Se 91%, Sp 84%, PPV 50%, NPV 98%). The ideal cut\u2010off for diagnosing non\u2010advanced liver fibrosis (Metavir \u22642) was &lt;10.2\u2009kPa (Se 55%, Sp 86%, PPV 90%, NPV 45%), correctly identifying 90% of patients. Data were validated in an independent cohort of 132 CHD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LSM is a useful tool for identifying patients at risk for liver cirrhosis and is superior to other NITs. The cut\u2010offs of &lt;10.2 and\u2009&lt;\u200915.2\u2009kPa reliably diagnose non\u2010advanced liver fibrosis and exclude cirrhosis in the majority of patients. However, LSM cannot completely replace liver biopsy in CHD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17878","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T05:00:53Z","timestamp":1705035653000},"page":"752-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Liver stiffness measurement as a noninvasive method for the diagnosis of liver cirrhosis in patients with chronic hepatitis D virus infection"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4425-2640","authenticated-orcid":false,"given":"Lisa","family":"Sandmann","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe Funded Project (no. 101057917)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-4669","authenticated-orcid":false,"given":"Elisabetta","family":"Degasperi","sequence":"additional","affiliation":[{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe Funded Project (no. 101057917)"},{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation, CRC \"A. M. and A. Migliavacca\" Center for Liver Disease University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Port","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo","family":"Aleman","sequence":"additional","affiliation":[{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe Funded Project (no. 101057917)"},{"name":"Department of Infectious Diseases Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Medicine Huddinge, Infectious Diseases Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Wallin","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc.  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Manuilov","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc.  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben L.","family":"Da","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc.  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe Funded Project (no. 101057917)"},{"name":"German Center for Infection Research (DZIF)  Hannover\/Braunschweig Germany"},{"name":"Centre for Individualised Infection Medicine Helmholtz Centre for Infection Research\/Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-7476","authenticated-orcid":false,"given":"Pietro","family":"Lampertico","sequence":"additional","affiliation":[{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe Funded Project (no. 101057917)"},{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation, CRC \"A. M. and A. Migliavacca\" Center for Liver Disease University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-3177","authenticated-orcid":false,"given":"Benjamin","family":"Maasoumy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"German Center for Infection Research (DZIF)  Hannover\/Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-0480","authenticated-orcid":false,"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe Funded Project (no. 101057917)"},{"name":"German Center for Infection Research (DZIF)  Hannover\/Braunschweig Germany"},{"name":"Department of Gastroenterology and Hepatology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Deterding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"Department of Gastroenterology and Hepatology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2021.05.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.20506"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1478\u20103231.2008.01802.X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0044930"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010323419"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRGASTRO.2016.86"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2021.06.011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15410"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2022.06.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2213429"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/LIV.13205"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/APT.13834"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"EtzionO YardeniD PalomA et\u00a0al.Noninvasive tests for detection of biopsy\u2010proven cirrhosis in chronic hepatitis D infected patients are suboptimal. 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