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Meta\u2010analysis of proportions for pooled estimates was performed. The method of inverse variance, employing a random\u2010effects model, was used to pool the hazard ratio (HR) comparing outcomes of abstinent against non\u2010abstinent individuals with alcohol\u2010associated cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 19 studies involving 18,833 people with alcohol\u2010associated cirrhosis. The prevalence of alcohol abstinence was 53.8% (CI: 44.6%\u201362.7%). Over a mean follow\u2010up duration of 48.6\u2009months, individuals who continued to consume alcohol had significantly lower overall survival compared to those who were abstinent (HR: 0.611, 95% CI: 0.506\u20130.738). These findings remained consistent in sensitivity\/subgroup analysis for the presence of decompensation, study design and studies that assessed abstinence throughout follow\u2010up. Alcohol abstinence was associated with a significantly lower risk of hepatic decompensation (HR: 0.612, 95% CI: 0.473\u20130.792).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Alcohol abstinence is associated with substantial improvement in overall survival in alcohol\u2010associated cirrhosis. However, only half of the individuals with known alcohol\u2010associated cirrhosis are abstinent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17888","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:28:51Z","timestamp":1706837331000},"page":"730-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Meta\u2010analysis: Prevalence and impact of alcohol abstinence in alcohol\u2010associated cirrhosis"],"prefix":"10.1111","volume":"59","author":[{"given":"Wen Hui","family":"Lim","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Tay","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-1569","authenticated-orcid":false,"given":"Cheng Han","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren Jun Hao","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen","family":"Ong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Hong","family":"Koh","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"},{"name":"National University Centre for Organ Transplantation, National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Teng","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"},{"name":"National University Centre for Organ Transplantation, National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Chee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen Yu","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Medicine, International Medical University  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Liver Center, Saga Medical School, Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-4743","authenticated-orcid":false,"given":"Mark","family":"Muthiah","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"},{"name":"National University Centre for Organ Transplantation, National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice X. 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