{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:45:35Z","timestamp":1784033135052,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metabolic associated fatty liver disease (MAFLD) is a relatively new term with limited studies done in South Asian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine prevalence and clinico\u2010epidemiological characteristics of MAFLD in general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted in randomly selected regions across Delhi, India. Data were collected on socio\u2010demographic particulars, health status and lifestyle factors. Anthropometric measurements, transient elastography, and laboratory investigations were carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 6146 participants (mean age: 43.1\u2009\u00b1\u200913.9\u2009years, 48.1% males) were included. The prevalence of MAFLD was 56.4% (<jats:italic>n<\/jats:italic>\u2009=\u20093468), of which lean MAFLD constituted 11.3%. Higher age (OR: 2.47; 95% CI: 2.21\u20132.76), low education level (OR: 1.23; 95% CI: 1.09\u20131.39), upper socio\u2010economic class (OR: 1.32; 95% CI: 1.17\u20131.49), and low physical activity (OR: 1.15; 95% CI: 1.03\u20131.28) were more common in MAFLD. The association of female sex with MAFLD differed in age groups &lt;40\u2009years (OR: 0.64 and 95% CI: 0.55\u20130.75) and &gt;40\u2009years (OR: 1.40 and 95% CI: 1.22\u20131.62) in both magnitude and direction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Liver fibrosis was present in 23% of the study population (32.2% among MAFLD group). Advanced liver fibrosis was three times more common in MAFLD group (6.2% vs 1.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Obesity and fibrosis had a statistically significant relationship and 75.8% of the individuals with advanced stages of fibrosis had obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nearly half of study population was found to have MAFLD. Advanced hepatic fibrosis was three times more common in these subjects. Aggressive public health measures are urgently required to raise awareness and introduce interventional strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17892","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:25:21Z","timestamp":1707287121000},"page":"843-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High prevalence of MAFLD in general population: A large cross\u2010sectional study calls for concerted public health action"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-6867","authenticated-orcid":false,"given":"Tushar","family":"Prabhakar","sequence":"first","affiliation":[{"name":"Department of Clinical Research and Epidemiology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-0013","authenticated-orcid":false,"given":"Manya","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Epidemiology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanica","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Epidemiology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka S.","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Epidemiology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Dubey","sequence":"additional","affiliation":[{"name":"Assistant Head Operations Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-5610","authenticated-orcid":false,"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-018-0317-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2021.11.010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23312"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.552737"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.12.022"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"S4","article-title":"Standards of medical Care in Diabetes\u20102016: summary of revisions","volume":"39","year":"2016","journal-title":"Diabetes Care"},{"key":"e_1_2_11_10_1","first-page":"163","article-title":"Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management","volume":"57","author":"Misra A","year":"2009","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2005898"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_1478_22"},{"key":"e_1_2_11_13_1","first-page":"689","article-title":"EASL clinical practice guidelines (CpGs) on non\u2010invasive tests for evaluation of liver disease severity and Prognosis\u20102021 update","volume":"75","author":"European Association for the Study of the Liver. 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