{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:04:49Z","timestamp":1768896289864,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reports of DILI due to herbal and dietary supplements have been increasing over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To characterise clinical, laboratory and histopathological phenotypes and outcomes of drug\u2010induced liver injury (DILI) due to anabolic\u2010androgenic steroids (AAS), selective androgen receptor modulators (SARMs), and bodybuilding supplements (BBS) in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case series. Patients presented to nine Australian tertiary hospitals, 2017\u20132023. DILI was defined biochemically and patients were included if their treating physician attributed DILI to preceding use of AAS, SARMs or BBS. Primary endpoint was time to normalisation of liver biochemistry. Secondary endpoints were hospitalisation for investigation or management of DILI, death attributable to liver injury, and liver transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three cases of DILI were identified, involving 40 drugs: 18 AAS, 14 SARMs and eight BBS. Patients were predominantly male (22\/23), with median age 30\u2009years (IQR 26\u201342). Most were symptomatic (21\/23). Median latency of onset was 58\u2009days (IQR 28\u2013112\u2009days) from drug commencement. Most patients (17\/23) were admitted to hospital. Based on updated Roussel Uclaf Causality Assessment Method, DILI was possible in 17\/23, probable in 2\/23 and unlikely in 4\/23. Median time to normalisation of liver biochemistry was 175\u2009days (IQR 70\u2013292\u2009days) from presentation. Three (3\/23) were treated with corticosteroids, 14\/23 were treated for itch, and one (1\/23) underwent liver transplantation. There were no deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prognosis of DILI from AAS, SARMs and BBS is good although liver transplantation may rarely be required. A detailed drug history is important in uncovering DILI due to these supplements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17906","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T09:09:43Z","timestamp":1708333783000},"page":"953-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Drug\u2010induced liver injury from selective androgen receptor modulators, anabolic\u2010androgenic steroids and bodybuilding supplements in Australia"],"prefix":"10.1111","volume":"59","author":[{"given":"Emily","family":"Nash","sequence":"first","affiliation":[{"name":"AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 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