{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:15:57Z","timestamp":1791825357728,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010132","name":"\u00d6sterreichische Nationalstiftung f\u00fcr Forschung, Technologie und Entwicklung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aetiological therapy improves liver function and may enable hepatic recompensation in decompensated cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We explored the potential for recompensation in patients with decompensated primary biliary cholangitis (PBC) \u2013 considering a biochemical response to ursodeoxycholic acid (UDCA) according to Paris\u2010II criteria as a surrogate for successful aetiological treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> were retrospectively included at the time of first decompensation. Recompensation was defined as (i) resolution of ascites and hepatic encephalopathy (HE) despite discontinuation of diuretic\/HE therapy, (ii) absence of variceal bleeding and (iii) sustained liver function improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 42 patients with <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> with decompensated cirrhosis (age: 63.5 [IQR: 51.9\u201369.2] years; 88.1% female; MELD\u2010Na: 13.5 [IQR: 11.0\u201315.0]) were included and followed for 41.9 (IQR: 11.0\u201370.9) months after decompensation. Seven patients (16.7%) achieved recompensation. Lower MELD\u2010Na (subdistribution hazard ratio [SHR]: 0.90; <jats:italic>p<\/jats:italic>\u2009=\u20090.047), bilirubin (SHR per mg\/dL: 0.44; <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and alkaline phosphatase (SHR per 10\u2009U\/L: 0.67; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) at decompensation, as well as variceal bleeding as decompensating event (SHR: 4.37; <jats:italic>p<\/jats:italic>\u2009=\u20090.069), were linked to a higher probability of recompensation. Overall, 33 patients were treated with UDCA for \u22651\u2009year and 12 (36%) achieved Paris\u2010II response criteria. Recompensation occurred in 5\/12 (41.7%) and in 2\/21 (9.5%) patients with vs. without UDCA response at 1\u2009year, respectively. Recompensation was linked to a numerically improved transplant\u2010free survival (HR: 0.46; <jats:italic>p<\/jats:italic>\u2009=\u20090.335). Nonetheless, 4\/7 recompensated patients presented with liver\u2010related complications after developing hepatic malignancy and\/or portal vein thrombosis and 2 eventually died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> and decompensated cirrhosis may achieve hepatic recompensation under UDCA therapy. However, since liver\u2010related complications still occur after recompensation, patients should remain under close follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17908","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T07:19:00Z","timestamp":1709018340000},"page":"962-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of potential hepatic recompensation criteria in patients with <scp>PBC<\/scp> and decompensated cirrhosis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-3372","authenticated-orcid":false,"given":"Benedikt Silvester","family":"Hofer","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of 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