{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:49:18Z","timestamp":1791668958914,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002733"],"award-info":[{"award-number":["UL1TR002733"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016058"],"award-info":[{"award-number":["P30CA016058"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>We examined the effects of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) initiation on long\u2010term Adverse Liver Outcomes (ALO) in patients with Metabolic Dysfunction\u2010Associated Steatotic Liver Disease (MASLD) cirrhosis and type 2 diabetes using real\u2010world data from the MarketScan database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of patients with MASLD cirrhosis and type 2 diabetes between 2012 and 2020. Cox proportional hazard models examine the association between GLP\u20101RAs initiation, modelled as time\u2010dependent, and the risk of ALO, a composite endpoint defined by the first occurrence of hepatic decompensation(s), portal hypertension, hepatocellular carcinoma (HCC) or liver transplantation (LT). We used Overlap Propensity Score Weighting (OPSW) to account for confounding. The study included 459 GLP\u20101RAs and 4837 non\u2010GLP\u20101RAs patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The non\u2010GLP\u20101RAs patients presented with 1411 (29%) ALO over 7431.7 person years, while GLP\u20101RAs patients had 32 (7%) ALO over 586.6 person years \u2013 risk rate difference 13.5 (95% CI: 11.4\u201315.7) per 100 person\u2010years. The OPSW\u2010adjusted risk of ALO was reduced by 36% (hazard ratio [HR]: 0.64; 95% CI: 0.54\u20130.76) in patients with vs. without GLP\u20101RAs initiation. GLP\u20101RAs initiation was associated with significant reductions in the adjusted risk of hepatic decompensation (HR: 0.74; 95% CI: 0.61\u20130.88), portal hypertension (HR: 0.73; 95% CI: 0.60\u20130.88), HCC (HR: 0.37; 95% CI: 0.20\u20130.63) and LT (HR: 0.24; 95% CI: 0.12\u20130.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of GLP\u20101RAs was associated with significant risk reductions in long\u2010term adverse liver outcomes, including hepatic decompensation, portal hypertension, HCC and LT, in MASLD cirrhosis patients with type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17925","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:08:19Z","timestamp":1711598899000},"page":"1096-1110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Impacts of glucagon\u2010like peptide\u20101 receptor agonists on the risk of adverse liver outcomes in patients with metabolic dysfunction\u2010associated steatotic liver disease cirrhosis and type 2 diabetes"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-2438","authenticated-orcid":false,"given":"Mohamed I.","family":"Elsaid","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics College of Medicine, The Ohio State University  Columbus Ohio USA"},{"name":"Center for Biostatistics College of Medicine, The Ohio State University  Columbus Ohio USA"},{"name":"Department of Internal Medicine, Division of Medical Oncology College of Medicine, The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-3214","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Hepatology &amp; Nutrition College of Medicine, The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-8633","authenticated-orcid":false,"given":"Stephen A.","family":"Firkins","sequence":"additional","affiliation":[{"name":"Digestive Disease and Surgery Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-5783","authenticated-orcid":false,"given":"Vinod K.","family":"Rustgi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"},{"name":"Center for Liver Diseases and Masses Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-8299","authenticated-orcid":false,"given":"Electra D.","family":"Paskett","sequence":"additional","affiliation":[{"name":"Division of Population Sciences The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"},{"name":"Department of Internal Medicine, Division of Cancer Prevention and Control College of Medicine, The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chathur","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Hepatology &amp; Nutrition College of Medicine, The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4898-7778","authenticated-orcid":false,"given":"K. 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