{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:29:16Z","timestamp":1793212156195,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The advent of new therapeutic agents and the improvement of supporting care might change the management of acute severe ulcerative colitis (ASUC) and avoid colectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the colectomy\u2010free survival and safety of a third\u2010line treatment in patients with ASUC refractory to intravenous steroids and who failed either infliximab or ciclosporin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre retrospective cohort\u00a0study of patients with ASUC refractory to intravenous steroids who had failed infliximab or ciclosporin and received a third\u2010line treatment during the same hospitalisation. Patients who stopped second\u2010line treatment due to disease activity or adverse events (AEs) were eligible. We assessed short\u2010term colectomy\u2010free survival by logistic regression analysis. Kaplan\u2013Meier curves and Cox regression models were used for long\u2010term assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 78 patients, 32 received infliximab and 46 ciclosporin as second\u2010line rescue treatment. Third\u2010line treatment was infliximab in 45 (58%), ciclosporin in 17 (22%), tofacitinib in 13 (17%) and ustekinumab in 3 (3.8%). Colectomy was performed in 29 patients (37%) during follow\u2010up (median 21\u2009weeks). Of the 78 patients, 32 and 18 were in clinical remission at, respectively, 12 and 52\u2009weeks. At the last visit, 25 patients were still on third\u2010line rescue treatment, while 12 had stopped it due to clinical remission. AEs were reported in 26 (33%) patients. Two patients died (2.6%), including one following colectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Third\u2010line rescue treatment avoided colectomy in over half of the patients with ASUC and may be considered a therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17938","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T12:30:30Z","timestamp":1709728230000},"page":"1248-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effectiveness and safety of a third\u2010line rescue treatment for acute severe ulcerative colitis refractory to infliximab or ciclosporin (<scp>REASUC<\/scp> study)"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-7005","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Gastroenterology and 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