{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:03:44Z","timestamp":1784937824920,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["15912"],"award-info":[{"award-number":["15912"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Imaging markers of biliary disease in primary sclerosing cholangitis (PSC) have potential for use in clinical and trial disease monitoring. Herein, we evaluate how quantitative magnetic resonance cholangiopancreatography (MRCP) metrics change over time, as per the natural history of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals with PSC were prospectively scanned using non\u2010contrast MRCP. Quantitative metrics were calculated using MRCP+ post\u2010processing software to assess duct diameters and dilated and strictured regions. Additionally, a hepatopancreatobiliary radiologist (blinded to clinical details, biochemistry and quantitative biliary metrics) reported each scan, including ductal disease assessment according to the modified Amsterdam Cholangiographic Score (MAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 14 quantitative MRCP+ metrics were found to be significantly different in patients with PSC (<jats:italic>N<\/jats:italic>\u2009=\u200955) compared to those with primary biliary cholangitis (<jats:italic>N<\/jats:italic>\u2009=\u200955), autoimmune hepatitis (<jats:italic>N<\/jats:italic>\u2009=\u200957) and healthy controls (<jats:italic>N<\/jats:italic>\u2009=\u200918). In PSC specifically, baseline metrics quantifying the number of strictures and the number and length of bile ducts correlated with the MAS, transient elastography and serum ALP values (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 for all correlations). Over a median 371\u2010day follow\u2010up (range: 364\u2013462), 29 patients with PSC underwent repeat MRCP, of whom 15 exhibited quantitative changes in MRCP+ metrics. Compared to baseline, quantitative MRCP+ identified an increasing number of strictures over time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Comparatively, no significant differences in biochemistry, elastography or the MAS were observed between timepoints. Quantitative MRCP+ metrics remained stable in non\u2010PSC liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quantitative MRCP+ identifies changes in ductal disease over time in PSC, despite stability in biochemistry, liver stiffness and radiologist\u2010derived cholangiographic assessment (trial registration: ISRCTN39463479).<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17944","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T05:19:13Z","timestamp":1712207953000},"page":"1366-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Quantitative <scp>MRCP<\/scp> and metrics of bile duct disease over time in patients with primary sclerosing cholangitis: A prospective study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-8087","authenticated-orcid":false,"given":"Palak 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Biomedical Research Centre (BRC) University of Birmingham  Birmingham UK"},{"name":"Institute of Immunology and Immunotherapy University of Birmingham  Birmingham UK"},{"name":"Liver Unit University Hospitals Birmingham Queen Elizabeth  Birmingham UK"},{"name":"Institute of Applied Health Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadir","family":"Abbas","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research and Gastrointestinal Research National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre (BRC) University of Birmingham  Birmingham UK"},{"name":"Institute of Immunology and Immunotherapy University of Birmingham  Birmingham UK"},{"name":"Liver Unit University Hospitals Birmingham Queen Elizabeth  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Telford","sequence":"additional","affiliation":[{"name":"Perspectum Ltd  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Young","sequence":"additional","affiliation":[{"name":"Perspectum Ltd  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarshi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Perspectum Ltd  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eddowes","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research and Gastrointestinal Research National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre (BRC) University of Birmingham  Birmingham UK"},{"name":"Institute of Immunology and Immunotherapy University of Birmingham  Birmingham UK"},{"name":"NIHR Nottingham BRC University of Nottingham  Nottingham UK"},{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik S.","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Division of Radiology University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-2255","authenticated-orcid":false,"given":"Gideon M.","family":"Hirschfield","sequence":"additional","affiliation":[{"name":"University Health Network and Department of Medicine Toronto Centre for Liver Disease University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60096-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093095"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.038"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28128"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313681"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30479"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30085"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.12.030"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000461"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.03.013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27825"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.01.019"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13402"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312354"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311739"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317993"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.112"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.05.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32771"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26620"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14797"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13899"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29293"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0618-8278(19)30812-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1860"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27113"},{"key":"e_1_2_9_31_1","first-page":"267A","article-title":"Determining the key features of biliary anatomy in quantitative MRCP for identifying patients with PSC","volume":"74","author":"Are V","year":"2021","journal-title":"Hepatology"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109884"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08142-y"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.27204"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06728-6"},{"key":"e_1_2_9_36_1","first-page":"1","article-title":"A risk prediction score based on magnetic resonance cholangiopancreatography (MRCP) accurately predicts disease progression in patients with primary sclerosing cholangitis (PSC)","volume":"66","author":"Muir A","year":"2017","journal-title":"Hepatology"},{"key":"e_1_2_9_37_1","unstructured":"Identifier: NCT04480840 Phase 2a Evaluation of Safety Tolerability and Pharmacokinetics of PLN\u201074809 in Patients With Primary 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