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There is growing interest in using the non\u2010haemoglobin contents of FIT residual buffer to enhance colonic neoplasia detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To establish from the literature a framework to catalogue candidate biomarkers within FIT residual buffer for non\u2010invasive colorectal cancer screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The search strategy evaluated PubMed, Scopus, Web of Science, Embase, and Google Scholar for publications through 25 October 2023, with search terms including FIT, buffer, OC\u2010sensor, biomarkers, microbiome, microRNA (miR), colon, rectum, screening, neoplasm, and early detection. Studies employing home\u2010based collection samples using quantitative FIT first processed for haemoglobin were included. One author reviewed all articles; a second author completed a 20% full\u2010text audit to ensure adherence to eligibility criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A broad search yielded 1669 studies and application of eligibility criteria identified 18 relevant studies. Multiple protein, DNA\/RNA, and microbiome biomarkers (notably haptoglobin, miR\u201016, miR\u201027a\u20103p, miR\u201092a, miR\u2010148a\u20103p, miR\u2010223, miR\u2010421, let\u20107b\u20105p, and <jats:italic>Tyzzerella 4<\/jats:italic>) were associated with colorectal neoplasia. Furthermore, studies highlighted the short\u2010term stability of biomarkers for clinical use and long\u2010term stability for research purposes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This scoping review summarises the framework and progress of research on stability of biomarkers in FIT residual buffer and their associations with colorectal neoplasia to guide opportunities for further confirmatory studies to enhance colorectal cancer screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17947","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:35:51Z","timestamp":1711546551000},"page":"1033-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systematic scoping review: Use of the faecal immunochemical test residual buffer to enhance colorectal cancer screening"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-0618","authenticated-orcid":false,"given":"Timothy","family":"McAuliffe","sequence":"first","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"},{"name":"Department of Veterans Affairs Medical Center White River Junction  Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin J.","family":"Larson","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"},{"name":"The Dartmouth Institute for Health Policy and Clinical Practice  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-3388","authenticated-orcid":false,"given":"Douglas J.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"},{"name":"Department of Veterans Affairs Medical Center White River Junction  Vermont 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