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Bioelectrical Impedance Analysis was used to assess skeletal mass muscle (SM) and phase angle (PhA). SM index (SMI) was calculated by dividing the SM by squared height. Muscle function was evaluated by hand grip strength (HGS) and timed up\u2010and\u2010go (TUG) test. Mixed\u2010effects linear regression models were fitted to SMI, HGS and physical performance and were used to test the effect of HCV eradication by DAA.<\/jats:p><\/jats:sec>Results<\/jats:title>62 outpatients (mean age, 58.6\u2009\u00b1\u200910.8\u2009years; 58% with compensated cirrhosis) were included. Significant decreases in liver fibrosis markers and an increase of 0.20 and 0.22\u2009kg\/m2<\/jats:sup> in the SMI were observed at T1 and T2. Following DAA therapy, an increase of one unit of PhA was associated with a reduction of 0.38\u2009min in TUG.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HCV eradication with DAA therapy was associated with a dynamic reduction of non\u2010invasive markers of liver fibrosis and increased muscle mass in 62 patients with CHC who had an undetectable HCV load at 12\u2009weeks after completion of antiviral treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17950","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T13:04:54Z","timestamp":1710853494000},"page":"1387-1401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Skeletal muscle mass increases after viral eradication with direct\u2010acting antivirals in patients with chronic hepatitis C: A longitudinal 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