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Onco\u2010Gastroenterology is a novel and emerging subspecialty within gastroenterology focused on cancer treatment\u2010related complications. Gastroenterologists must be prepared to identify and manage diverse immune\u2010mediated toxicities including enterocolitis, hepatitis, pancreatitis and other ICI\u2010induced toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To provide a narrative review of the epidemiology, diagnostic evaluation and management of checkpoint inhibitor\u2010induced gastrointestinal and hepatic toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Cochrane and PubMed databases for articles published through August 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gastrointestinal and hepatic irAEs include most commonly enterocolitis and hepatitis, but also pancreatitis, oesophagitis, gastritis, motility disorders (gastroparesis) and other rarer toxicities. Guidelines from the National Comprehensive Cancer Network, American Society of Clinical Oncology and European Society for Medical Oncology, in combination with emerging cohort and clinical trial data, offer strategies for management of ICI toxicities. Evaluation of irAEs severity by formal classification and clinical stability, and a thorough workup for alternative etiologies which may clinically mimic irAEs underlie initial management. Treatments include corticosteroids, biologics and other immunosuppressive agents plus supportive care; decisions on dosing, timing and choice of steroid adjuncts and potential for subsequent checkpoint inhibitor dosing are nuanced and toxicity\u2010specific.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Expanding clinical trial and cohort data have clarified the epidemiology and clinical characteristics of gastrointestinal, pancreatic and hepatic toxicities of ICIs. Guidelines, though valuable, remain based principally on retrospective cohort data. Quality prospective, controlled studies may refine algorithms for treatment and potential immunotherapy rechallenge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17980","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T05:32:30Z","timestamp":1712640750000},"page":"1350-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Review article: Contemporary management of gastrointestinal, pancreatic and hepatic toxicities of immune checkpoint inhibitors"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-961X","authenticated-orcid":false,"given":"Matthew J.","family":"Townsend","sequence":"first","affiliation":[{"name":"Department of Medicine Duke University Hospital  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac J.","family":"Benque","sequence":"additional","affiliation":[{"name":"University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Li","sequence":"additional","affiliation":[{"name":"University of California San Francisco School of Medicine  San Francisco California USA"},{"name":"Division of Gastroenterology University of California San Francisco Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-6843","authenticated-orcid":false,"given":"Shilpa","family":"Grover","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Endoscopy Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts 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