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These symptoms can have profound negative effects on the quality of life of affected patients and can be difficult to treat. They may be caused by IBD\u2010related complications or comorbid disorders, but they can also be explained by irritable bowel syndrome (IBS)\u2010like symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To provide a practical step\u2010by\u2010step guide to diagnose and treat persistent gastrointestinal symptoms in patients with IBD in remission via a personalised approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We scrutinised relevant literature on causes, diagnostics and treatment of persistent gastrointestinal symptoms (abdominal pain or discomfort, bloating, abdominal distension, diarrhoea, constipation and faecal incontinence) in patients with IBD in remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A graphical practical guide for several steps in diagnosing, identifying potential triggers and adequate treatment of persistent gastrointestinal symptoms in IBD in remission is provided based on supporting literature. The first part of this review focuses on the diagnostic and treatment approaches for potential IBD\u2010related complications and comorbidities. The second part describes the approach to IBS\u2010like symptoms in IBD in remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persistent gastrointestinal symptoms in IBD in remission can be traced back to potential pathophysiological mechanisms in individual patients and can be treated adequately. For both IBD\u2010related complications and comorbidities and IBS\u2010like symptoms in IBD in remission, pharmacological, dietary, lifestyle or psychological treatments can be effective. A systematic and personalised approach is required to reduce the burden for patients, healthcare systems, and society.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17988","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T05:46:57Z","timestamp":1712641617000},"page":"1470-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Review article: A practical approach to persistent gastrointestinal symptoms in inflammatory bowel disease in remission"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8082-3462","authenticated-orcid":false,"given":"Arta","family":"Aliu","sequence":"first","affiliation":[{"name":"Department Gastroenterology and Hepatology Maastricht University Medical Center+  Maastricht the Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1788-2199","authenticated-orcid":false,"given":"Daan H. 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