{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:52:52Z","timestamp":1790175172139,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22fk0210094"],"award-info":[{"award-number":["22fk0210094"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A multi\u2010stakeholder consensus has proposed MASLD (metabolic dysfunction\u2010associated steatotic liver disease). We aimed to investigate the pathological findings related to the mid\u2010term mortality of patients with biopsy\u2010proven MASLD in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 1349 patients with biopsy\u2010proven MASLD. The observational period was 8010 person years. We evaluated independent factors associated with mortality in patients with MASLD by Cox regression analysis. We also investigated pathological profiles related to mortality in patients with MASLD using data\u2010mining analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of MASH and stage 3\/4 fibrosis was observed in 65.6% and 17.4%, respectively. Forty\u2010five patients with MASLD died. Of these, liver\u2010related events were the most common cause at 40% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918), followed by extrahepatic malignancies at 26.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912). Grade 2\/3 lobular inflammation and stage 3\/4 fibrosis had a 1.9\u2010fold and 1.8\u2010fold risk of mortality, respectively. In the decision\u2010tree analysis, the profiles with the worst prognosis were characterised by Grade 2\/3 hepatic inflammation, along with advanced ballooning (grade 1\/2) and fibrosis (stage 3\/4). This profile showed a mortality at 8.3%. Furthermore, the random forest analysis identified that hepatic fibrosis and inflammation were the first and second responsible factors for the mid\u2010term prognosis of patients with MASLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with biopsy\u2010proven MASLD, the prevalence of MASH and advanced fibrosis was approximately 65% and 20%, respectively. The leading cause of mortality was liver\u2010related events. Hepatic inflammation and fibrosis were significant factors influencing mid\u2010term mortality. These findings highlight the importance of targeting inflammation and fibrosis in the management of patients with MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17995","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:35:29Z","timestamp":1713846929000},"page":"1559-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hepatic inflammation and fibrosis are profiles related to mid\u2010term mortality in biopsy\u2010proven MASLD: A multicenter study in Japan"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-9874","authenticated-orcid":false,"given":"Tsubasa","family":"Tsutsumi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Kurume University School of Medicine  Kurume 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