{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:44:28Z","timestamp":1793227468387,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["WI213008"],"award-info":[{"award-number":["WI213008"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["113202001"],"award-info":[{"award-number":["113202001"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on cost\u2010effectiveness of first\u2010line infliximab in paediatric patients with Crohn's disease are limited. Since biologics are increasingly prescribed and accompanied by high costs, this knowledge gap needs to be addressed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the cost\u2010effectiveness of first\u2010line infliximab compared to conventional treatment in children with moderate\u2010to\u2010severe Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients from the Top\u2010down Infliximab Study in Kids with Crohn's disease randomised controlled trial. Children with newly diagnosed moderate\u2010to\u2010severe Crohn's disease were treated with azathioprine maintenance and either five induction infliximab (biosimilar) infusions or conventional induction treatment (exclusive enteral nutrition or corticosteroids). Direct healthcare consumption and costs were obtained per patient until week 104. This included data on outpatient hospital visits, hospital admissions, drug costs, endoscopies and surgeries. The primary health outcome was the odds ratio of being in clinical remission (weighted paediatric Crohn's disease activity index&lt;12.5) during 104\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 89 patients (44 in the first\u2010line infliximab group and 45 in the conventional treatment group). Mean direct healthcare costs per patient were \u20ac36,784 for first\u2010line infliximab treatment and \u20ac36,874 for conventional treatment over 2\u2009years (<jats:italic>p<\/jats:italic>\u2009=\u20090.981). The odds ratio of first\u2010line infliximab versus conventional treatment to be in clinical remission over 104\u2009weeks was 1.56 (95%CI 1.03\u20132.35, <jats:italic>p<\/jats:italic>\u2009=\u20090.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010line infliximab treatment resulted in higher odds of being in clinical remission without being more expensive, making it the dominant strategy over conventional treatment in the first 2\u2009years after diagnosis in children with moderate\u2010to\u2010severe Crohn's disease.<\/jats:p><jats:p>Trial registration number: NCT02517684.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18000","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T04:59:25Z","timestamp":1713761965000},"page":"1510-1520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Randomised clinical trial: First\u2010line infliximab biosimilar is cost\u2010effective compared to conventional treatment in paediatric Crohn's disease"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-7241","authenticated-orcid":false,"given":"Stephanie A.","family":"Vuijk","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology Erasmus Medical Center\/Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M. E.","family":"Jongsma","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Erasmus Medical Center\/Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt M.","family":"Hoeven","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Erasmus Medical Center\/Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten A.","family":"Cozijnsen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Erasmus Medical Center\/Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel","family":"van Pieterson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Erasmus Medical Center\/Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim G. J.","family":"de Meij","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children's Hospital Amsterdam UMC, VU University  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obbe F.","family":"Norbruis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Isala Hospital  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Groeneweg","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Maasstad Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorien M.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology UMC Utrecht\/Wilhelmina Children's Hospital  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"van Wering","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Amphia Hospital  Breda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Medical Spectrum Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Stapelbroek","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathelijne","family":"van der Feen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Jeroen Bosch Hospital  's Hertogenbosch The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-2665","authenticated-orcid":false,"given":"Patrick F.","family":"van Rheenen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology University Medical Center, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel P.","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children's Hospital Amsterdam UMC, VU University  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Teklenburg","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Isala Hospital  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Rizopoulos","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus MC  Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten J.","family":"Poley","sequence":"additional","affiliation":[{"name":"Institute for Medical Technology Assessment and Erasmus School of Health Policy &amp; 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