{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T22:12:48Z","timestamp":1767046368312,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endoscopic healing (EH) is a therapeutic target in ulcerative colitis (UC). However, even patients who have achieved EH relapse frequently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the association between recent steroid use and relapse risk in UC patients with EH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multi\u2010centre cohort study included 1212 UC patients with confirmed EH (Mayo endoscopic subscore \u22641). We excluded patients with current systemic steroid use or history of advanced therapy. We divided patients into a recent steroid group (last systemic steroid use within 1\u2009year; <jats:italic>n<\/jats:italic>\u2009=\u200959) and a non\u2010recent or steroid\u2010na\u00efve group (<jats:italic>n<\/jats:italic>\u2009=\u20091153). We followed the patients for 2\u2009years to evaluate relapse, defined as induction of systemic steroids or advanced therapy. We used logistic regression to estimate the odds ratio (OR) of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relapse occurred in 28.8% of the recent steroid group and 5.6% of the non\u2010recent\/steroid\u2010na\u00efve group (multi\u2010variable\u2010adjusted OR 5.53 [95% CI 2.85\u201310.7]). The risk of relapse decreased with time since the last steroid use: 28.8% for less than 1\u2009year after steroid therapy, 22.9% for 1\u2009year, 16.0% for 2\u2009years and 7.9% beyond 3\u2009years, approaching 4.0% in steroid\u2010na\u00efve patients. (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even for patients with UC who achieved EH, the risk of relapse remains high following recent steroid therapy. Physicians need to consider the duration since last steroid use to stratify the relapse risk in UC patients with EH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18013","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T12:23:58Z","timestamp":1713875038000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recent steroid use and the relapse risk in ulcerative colitis patients with endoscopic healing"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-5002","authenticated-orcid":false,"given":"Tomohiro","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Yokohama Municipal Citizen's Hospital  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Miyatani","sequence":"additional","affiliation":[{"name":"Centre for Advanced IBD Research and Treatment Kitasato University Kitasato Institute Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunaki","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Nagoya University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Fukuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Nerima Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-3782","authenticated-orcid":false,"given":"Hiroki","family":"Kiyohara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Morikubo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dokkyo Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Kakimoto","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Medicine Shiga University of Medical Science  Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2569-219X","authenticated-orcid":false,"given":"Katsuki","family":"Yaguchi","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Centre Yokohama City University Medical Centre  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shojiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-5488","authenticated-orcid":false,"given":"Katsuyoshi","family":"Ando","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology\/Oncology, Department of Medicine Asahikawa Medical University  Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Nishimata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sameshima Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-9294","authenticated-orcid":false,"given":"Takeo","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Osaka 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