{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:49:08Z","timestamp":1788544148735,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sofosbuvir, velpatasvir and voxilaprevir (SOF\/VEL\/VOX) is the recommended rescue therapy for patients with chronic hepatitis C infection who fail direct\u2010acting antivirals (DAAs). Data are limited on the effectiveness of this treatment after the current first\u2010line therapies. Our aim was to analyse the effectiveness and safety of SOF\/VEL\/VOX among patients failing sofosbuvir\/velpatasvir (SOF\/VEL) or glecaprevir\/pibrentasvir (GLE\/PIB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective multicentre study (26 Spanish hospitals), including chronic hepatitis C patients unsuccessfully treated with SOF\/VEL or GLE\/PIB, and retreated with SOF\/VEL\/VOX\u2009\u00b1\u2009ribavirin for 12\u2009weeks between December 2017 and December 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 142 patients included: 100 (70.4%) had failed SOF\/VEL and 42 (29.6%) GLE\/PIB. Patients were mainly men (84.5%), White (93.9%), with hepatitis C virus genotype (GT) 3 (49.6%) and 47.2% had liver cirrhosis. Sustained virological response (SVR) was evaluated in 132 patients who completed SOF\/VEL\/VOX and were followed 12\u2009weeks after end of treatment; 117 (88.6%) achieved SVR. There were no significant differences in SVR rates according to initial DAA treatment (SOF\/VEL 87.9% vs. GLE\/PIB 90.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8), cirrhosis (no cirrhosis 90% vs. cirrhosis 87.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6) or GT3 infection (non\u2010GT3 91.9% vs. GT3 85.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3). However, when considering the concurrent presence of SOF\/VEL treatment, cirrhosis and GT3 infection, SVR rates dropped to 82.8%. Ribavirin was added in 8 (6%) patients, all achieved SVR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SOF\/VEL\/VOX is an effective rescue therapy for failures to SOF\/VEL or GLE\/PIB, with an SVR of 88.6%. Factors previously linked to lower SVR rates, such as GT3 infection, cirrhosis and first\u2010line therapy with SOF\/VEL were not associated with lower SVRs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18020","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T03:45:11Z","timestamp":1714621511000},"page":"201-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Real\u2010life effectiveness of sofosbuvir\/velpatasvir\/voxilaprevir in hepatitis C patients previously treated with sofosbuvir\/velpatasvir or glecaprevir\/pibrentasvir"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2239-4939","authenticated-orcid":false,"given":"Juan Carlos","family":"Ruiz\u2010Cobo","sequence":"first","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"},{"name":"Liver Unit, Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9011-3954","authenticated-orcid":false,"given":"Jordi","family":"Llaneras","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"},{"name":"Liver Unit, Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-1764","authenticated-orcid":false,"given":"Xavier","family":"Forns","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Cl\u00ednic  Barcelona Spain"},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"},{"name":"University of Barcelona (UB)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8423-6787","authenticated-orcid":false,"given":"Adolfo","family":"Gallego\u00a0Moya","sequence":"additional","affiliation":[{"name":"Servicio de Patolog\u00eda Digestiva Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-2233","authenticated-orcid":false,"given":"Isabel","family":"Conde\u00a0Amiel","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplantation Unit Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-7563","authenticated-orcid":false,"given":"Ana","family":"Arencibia","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-2433","authenticated-orcid":false,"given":"Moises","family":"Diago","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Valencia  Valencia Spain"},{"name":"Medicine Department Universidad de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-0855","authenticated-orcid":false,"given":"Javier","family":"Garc\u00eda\u2010Samaniego","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Liver Unit Hospital Universitario La Paz  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Hospital Universitario La Paz (IdiPAZ)  Madrid 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