{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:21:46Z","timestamp":1791825706911,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012276","name":"Tillotts Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The introduction of biologic therapies and the \u2018treat\u2010to\u2010target\u2019 treatment strategy may have changed the disease course of ulcerative colitis (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe the early disease course and disease outcome at 1\u2010year follow\u2010up in a population\u2010based inception cohort of adult patients with newly diagnosed UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Inflammatory Bowel Disease in South\u2010Eastern Norway (IBSEN) III study is a population\u2010based inception cohort study with prospective follow\u2010up. Patients newly diagnosed with inflammatory bowel disease during 2017\u20132019 were included. Patients \u226518\u2009years at diagnosis of UC who attended the 1\u2010year follow\u2010up were investigated. We registered clinical, endoscopic and demographic data at diagnosis and 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 877 patients with UC (median age 36\u2009years (range: 18\u201384), 45.8% female). At diagnosis, 39.2% presented with proctitis, 24.7% left\u2010sided colitis and 36.0% extensive colitis. At the 1\u2010year follow\u2010up, 13.9% experienced disease progression, and 14.5% had received one or more biologic therapies. The colectomy rate was 0.9%. Steroid\u2010free clinical remission was observed in 76.6%, and steroid\u2010free endoscopic remission in 68.7%. Anaemia and initiation of systemic steroid treatment at diagnosis were associated with biologic therapy within the first year after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this population\u2010based inception cohort, colectomy rate in the first year after diagnosis was low, and a high proportion of patients were in remission at 1\u2010year follow\u2010up. The use of biologic therapy increases, consistent with findings from previous studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18097","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T21:22:15Z","timestamp":1717536135000},"page":"357-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical course of ulcerative colitis: Frequent use of biologics and low colectomy rate first year after diagnosis\u2014results from the IBSEN III inception cohort"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9121-6807","authenticated-orcid":false,"given":"Vibeke","family":"Strande","sequence":"first","affiliation":[{"name":"Unger\u2010Vetlesen Institute, Lovisenberg Diaconal Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, University of Oslo  Oslo 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