{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:34:58Z","timestamp":1791560098299,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rapidity of effect of advanced therapies for patients with Crohn's disease (CD) can be an essential decision parameter; however, comparative evaluation is lacking. We aimed to compare early response for advanced CD therapies in a network meta\u2010analysis (NMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched systematically MEDLINE, Embase, and CENTRAL up to 19 February 2024, for randomised controlled trials. The co\u2010primary outcomes were induction of clinical remission (Crohn's Disease Activity Index (CDAI) \u2264150) and clinical response (\u2265100\u2010point reduction in CDAI) within the first 6\u2009weeks of treatment. We incorporated any assessment within this time point in a Bayesian random\u2010effects NMA following PRISMA\u2010NMA guidance (PROSPERO ID: CRD42022368509).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010five studies, comprising 7414 patients, were included. Infliximab combined with azathioprine or monotherapy ranked highest for induction of clinical remission within 6\u2009weeks and was significantly superior to certolizumab, ustekinumab, guselkumab, vedolizumab, and upadacitinib. However, superiority over risankizumab 600\u2009mg and adalimumab 160\/80\u2009mg was non\u2010significant. Accordingly, infliximab in combination with azathioprine and guselkumab 600\u2009mg ranked highest in the corresponding analysis of clinical response with no statistical significance demonstrated. Among bio\u2010exposed patients, none of whom received infliximab, upadacitinib, and risankizumab induced the highest clinical responses. On the other hand, vedolizumab, certolizumab, and ustekinumab ranked lowest across the analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found infliximab to be ranked highest and superior to all other agents but risankizumab and adalimumab, demonstrating the highest probability of early induction of remission. Upadacitinib and risankizumab induced the highest clinical responses in bio\u2010exposed patients. However, infliximab was not investigated in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18110","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:54:08Z","timestamp":1718153648000},"page":"124-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Network meta\u2010analysis: Comparative onset of early effect of biologics and small molecules in moderately to severely active luminal Crohn's disease"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-7030","authenticated-orcid":false,"given":"Mohamed","family":"Attauabi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Copenhagen University Hospital\u2014Herlev and Gentofte  Herlev Denmark"},{"name":"Gastrounit, Medical Section Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-4212","authenticated-orcid":false,"given":"Casper","family":"Steenholdt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Copenhagen University Hospital\u2014Herlev and Gentofte  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-3467","authenticated-orcid":false,"given":"Anja","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Bispebjerg University Hospital  Bispebjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6037-2883","authenticated-orcid":false,"given":"John","family":"Gubatan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-5139","authenticated-orcid":false,"given":"Johan","family":"Burisch","sequence":"additional","affiliation":[{"name":"Gastrounit, Medical Section Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-8635","authenticated-orcid":false,"given":"Ole Haagen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Copenhagen University Hospital\u2014Herlev and Gentofte  Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3230-7966","authenticated-orcid":false,"given":"Jakob Benedict","family":"Seidelin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Copenhagen University Hospital\u2014Herlev and Gentofte  Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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