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We aimed to characterise the psychiatric burden in HCC, risk factors for incident diagnosis and treatment patterns over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using IQVIA PharMetrics\u00ae Plus for Academics\u2014a nationally representative claims database of the commercially insured US population\u2014we identified psychiatric diagnoses and treatment among patients with newly diagnosed HCC. Multivariable logistic regression modelling identified factors associated with psychiatric diagnosis and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 11,609 patients with HCC, 2166 (18.6%) had a psychiatric diagnosis after cancer diagnosis with depression (58.3%) and anxiety (53.0%) being most common. Women (aOR 1.33, 95% CI [1.19\u20131.49]), pre\u2010existing psychiatric diagnoses (aOR 9.12 [8.08\u201310.3]) and HCC treatment type (transplant: aOR 2.15 [1.66\u20132.77]; locoregional therapies: aOR 1.74 [1.52\u20131.99]; hospice: aOR 2.43 [1.79\u20133.29]) were significantly associated with psychiatric diagnosis. Female sex, ascites, higher comorbidity and treatment type were associated with incident psychiatric diagnosis. Pharmacotherapy was used in 1392 (64.3%) patients with a psychiatric diagnosis, with antidepressants (46.2%) and anxiolytics (32.8%) being most common. Psychiatric diagnoses increased from 14.8% in 2006\u20132009 to 21.1% in 2018\u20132021 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In almost 20% of patients with pre\u2010existing psychiatric conditions, therapy was discontinued after HCC diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nearly 2 of 10 patients with HCC were diagnosed with a psychiatric condition after cancer diagnosis with unique sociodemographic and clinical risk factors identified. This highlights a risk for increased psychological burden in need of early evaluation and treatment among patients with newly diagnosed HCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18115","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T05:54:37Z","timestamp":1718171677000},"page":"469-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Psychiatric disorders in patients with hepatocellular carcinoma: A large <scp>US<\/scp> cohort of commercially insured individuals"],"prefix":"10.1111","volume":"60","author":[{"given":"Mausam J.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas 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