{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T16:31:39Z","timestamp":1775493099125,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK083020"],"award-info":[{"award-number":["U01DK083020"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK083027"],"award-info":[{"award-number":["U01DK083027"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK100928"],"award-info":[{"award-number":["U01DK100928"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U24DK065176"],"award-info":[{"award-number":["U24DK065176"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In April 2022, French Lentil and Leek Crumble (FLLC), a new frozen food preparation manufactured by Daily Harvest\u2122 (containing <jats:italic>Tara<\/jats:italic> flour) was offered as a natural high\u2010protein meal product. Soon thereafter, widespread anecdotal reports of acute gastrointestinal symptoms with liver injury were reported, leading to its voluntary withdrawal in June 2022, after shipment of 28,000 preparations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To summarise the clinical and laboratory features of 17 patients with FLLC associated liver injury from the Drug Induced Liver Injury Network (DILIN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with FLLC\u2010associated liver injury were enrolled into a prospective protocol and followed for 6\u2009months. Cases were adjudicated by expert opinion causality assessment with summary statistics for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Enrolled subjects had a mean age of 41\u2009years, 82% were female with mean BMI of 24\u2009kg\/m<jats:sup>2<\/jats:sup>. All were Caucasian without underlying liver disease. In most cases, abdominal pain and nausea arose within hours of FLLC ingestion. Mean days from ingestion to identification of liver injury was 3.1\u2009days (\u00b12.8). On enrolment, 53% had jaundice, 47% nausea, 24% fever, 59% abdominal pain, 41% itching and 12% rash. The mean initial serum ALT was 475\u2009U\/L (\u00b1302), AST 315\u2009U\/L (\u00b1315), alkaline phosphatase 190\u2009U\/L (\u00b176), with a total bilirubin of 2.6\u2009mg\/dL (\u00b12). In this study, 63% presented with a hepatocellular pattern of liver injury, 6% cholestatic and 31% mixed as determined by the <jats:italic>R<\/jats:italic> value. In addition, 24% of patients were hospitalised, and there were no fatalities or liver transplants. Liver biopsy in one subject revealed acute hepatitis with mild ductular reaction, mild lymphocytic and eosinophilic portal inflammation, mild lobular inflammation, preserved bile ducts and absence of interface hepatitis, steatosis, granulomatous reaction or cholestasis. Phylogenetic analysis confirmed the presence of <jats:italic>Tara spinosa<\/jats:italic>, the source of <jats:italic>Tara<\/jats:italic> flour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Natural food products are increasingly ubiquitous and may unexpectedly cause significant illness. All clinicians should inquire whether patients are consuming natural food products or herbal supplements and consider them as a potential cause of liver injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18116","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T13:29:26Z","timestamp":1718371766000},"page":"479-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterisation of an outbreak of acute liver injury after ingestion of plant\u2010based food supplement"],"prefix":"10.1111","volume":"60","author":[{"given":"Gina","family":"Choi","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine, University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-2349","authenticated-orcid":false,"given":"Jawad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine, Mt. 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Sinai Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikhlas","family":"Khan","sequence":"additional","affiliation":[{"name":"University of Mississippi  Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharathi","family":"Avula","sequence":"additional","affiliation":[{"name":"University of Mississippi  Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiman","family":"Barnhart","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1443-9351","authenticated-orcid":false,"given":"Andrew","family":"Stolz","sequence":"additional","affiliation":[{"name":"University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Drug\u2010Induced Liver Injury Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.3.281"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2374373517706612"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665121003748"},{"key":"e_1_2_10_5_1","unstructured":"Nutrition C for FS and A. Investigation of adverse event reports: French Lentil & Leek Crumbles (June 2022). FDA Published Online October 16 2023 [cited 2023 Dec 21]. Available from:https:\/\/www.fda.gov\/food\/outbreaks\u2010foodborne\u2010illness\/investigation\u2010adverse\u2010event\u2010reports\u2010french\u2010lentil\u2010leek\u2010crumbles\u2010june\u20102022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010200932010\u201000005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23577"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.3c00100"},{"key":"e_1_2_10_9_1","unstructured":"Acevedo\u2010Rodr\u00edguezP StrongMT.Catalogue of seed plants of the West Indies. Published Online 2012 [cited 2023 Dec 21]. Available from:http:\/\/repository.si.edu\/xmlui\/handle\/10088\/17551"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31538"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.08.015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.09.026"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25825"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2011.602688"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2020.05.003"},{"key":"e_1_2_10_16_1","unstructured":"Updates on our voluntary recall of French lentil + leek crumbles [cited 2023 Dec 21]. Available from:https:\/\/www.daily\u2010harvest.com\/content\/french\u2010lentil\u2010leek\u2010crumbles\u2010advisory"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0000964648.61550.ec"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2023.2256469"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/1475636031000152277"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007260170017"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.10.5160\u20105163.2002"},{"key":"e_1_2_10_22_1","article-title":"Plant toxin in undercooked kidney beans behind French outbreak","volume":"20","author":"Desk N","year":"2023","journal-title":"Food Safety News"},{"key":"e_1_2_10_23_1","unstructured":"OxyELITE Pro. In:LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases;2012. [cited 2024 April 28]. Available from:http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548935\/"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.18116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T06:00:31Z","timestamp":1721714431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.18116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/apt.18116"],"URL":"https:\/\/doi.org\/10.1111\/apt.18116","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"2024-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}