{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:04:24Z","timestamp":1792217064055,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RA) show anti\u2010inflammatory properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate their clinical impact on inflammatory bowel disease (IBD) outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study utilising the TriNetX database comparing IBD\u2010specific outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) and type 2 diabetes mellitus (T2DM) on GLP\u20101RA compared to oral hypoglycaemic agents. The primary outcome was hospitalisation requiring intravenous steroids and IBD\u2010related surgery within 3\u2009years. We performed 1:1 propensity score matching (PSM) for demographics, co\u2010morbid conditions, BMI, laboratory values, HbA1c, and IBD medications including steroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 1130 patients in the UC GLP\u20101RA cohort (mean age: 58.9\u2009\u00b1\u200911.6\u2009years, 56.3% female, 70.2% White, 57.2% with obesity) and 1140 patients in the CD GLP\u20101RA cohort (mean age: 56.7\u2009\u00b1\u200911.5, 61.9% female, 73.6% White, 56.2% with obesity). After PSM, there was no difference in the risk of intravenous steroid use (aHR: 1.21, 95% CI: 0.92\u20131.59) but a lower risk of colectomy (aHR: 0.37, 95% CI: 0.14\u20130.97) between the UC GLP\u20101RA and control cohort. There was no difference in the risk of intravenous steroid use (aHR: 1.04, 95% CI: 0.80\u20131.34) but a lower risk of surgery (aHR: 0.55, 95% CI: 0.36\u20130.84) between the CD GLP\u20101RA and CD control cohort. There was no difference in the risk of oral steroid use or advanced therapy initiation in the UC and CD GLP\u20101RA than control cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found an association between lower risk of IBD\u2010related surgery and GLP\u20101RA use for T2DM in patients with UC or CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18138","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T02:34:08Z","timestamp":1719542048000},"page":"620-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Use of glucagon\u2010like peptide\u20101 receptor agonists for type 2 diabetes mellitus and outcomes of inflammatory bowel disease"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-7712","authenticated-orcid":false,"given":"Aakash","family":"Desai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Petrov","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana G.","family":"Hashash","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaumik","family":"Brahmbhatt","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-2760","authenticated-orcid":false,"given":"Gursimran S.","family":"Kochhar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Allegheny Health Network  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis A.","family":"Farraye","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106320"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.13361"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.23937\/2378\u20103656\/1410281"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201088612\u2010x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9040383"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679\u2010023\u201000506\u20103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000847"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204953"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.08.004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3148"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac131"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.09.011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjae008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135858"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6222"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109230"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.887497"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100979"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(18)30024\u2010x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14497"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23619"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/clep.s391819"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izae090"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k872"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019827852"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010145"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2021.2002616"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.1957"}],"container-title":["Alimentary Pharmacology &amp; 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