{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:41:45Z","timestamp":1791492105549,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011751","name":"Stiftelsen f\u00f6r Strategisk Forskning","doi-asserted-by":"publisher","award":["RB13\u2010016"],"award-info":[{"award-number":["RB13\u2010016"]}],"id":[{"id":"10.13039\/501100011751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020\u201002021"],"award-info":[{"award-number":["2020\u201002021"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Faecal biomarkers can be used to assess inflammatory bowel disease (IBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore the performance of some promising biomarkers in diagnosing and predicting disease course in IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 65 patients with treatment\u2010na\u00efve, new\u2010onset Crohn's disease (CD), 90 with ulcerative colitis (UC), 67 symptomatic controls (SC) and 41 healthy controls (HC) in this prospective observational study. We analysed faecal samples for calprotectin (FC), myeloperoxidase (MPO), human neutrophil lipocalin (HNL), eosinophil cationic protein ECP and eosinophil\u2010derived neurotoxin (EDN) and compared markers among groups. We assessed the diagnostic capability of biomarkers with receiver operating characteristic curves. Clinical disease course was determined for each patient with IBD and analysed the association with biomarkers by logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All markers were elevated at inclusion in patients with IBD compared with HC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and SC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). FC (AUC 0.85, 95% CI: 0.79\u20130.89) and MPO (AUC 0.85, 95% CI: 0.80\u20130.89) showed the highest diagnostic accuracy in distinguishing IBD from SC. The diagnostic ability of biomarkers differed between IBD subtypes with the highest performance for FC and MPO in CD. The diagnostic accuracy was further improved by combining FC and MPO (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Levels of FC, MPO and HNL at inclusion were predictive of an aggressive disease course with MPO showing the strongest association (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study\u00a0provides new insight into the diagnostic and prognostic capability of neutrophil and eosinophil biomarkers in IBD and suggests that MPO, alone or in combination with FC, may add to the diagnostic power of faecal biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18154","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:14:36Z","timestamp":1720829676000},"page":"765-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Faecal biomarkers for diagnosis and prediction of disease course in treatment\u2010na\u00efve patients with\n                    <scp>IBD<\/scp>"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-7990","authenticated-orcid":false,"given":"Maria","family":"Ling\u00a0Lundstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Gastroenterology Research Group Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Chemistry Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-8516","authenticated-orcid":false,"given":"Charlotte R. H.","family":"Hedin","sequence":"additional","affiliation":[{"name":"Karolinska Institute Department of Medicine Solna  Stockholm Sweden"},{"name":"Gastroenterology Unit, Department of Gastroenterology, Dermatovenereology and Rheumatology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-0746","authenticated-orcid":false,"given":"Daniel","family":"Bergemalm","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lampinen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria K.","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa V.","family":"Keita","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Laboratory, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl M\u00e5rten","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Repsilber","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"D'Amato","sequence":"additional","affiliation":[{"name":"Gastrointestinal Genetics Lab, CIC BioGUNE\u2013BRTA  Derio Spain"},{"name":"Ikerbasque, Basque Foundation for Science  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hjortswang","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine, and Caring Sciences Link\u00f6ping University  Linkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Strid","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Gastroenterology, Dermatovenereology and Rheumatology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"BIOIBD Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan D.","family":"S\u00f6derholm","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Surgery Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-2106","authenticated-orcid":false,"given":"Lena","family":"\u00d6hman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Venge","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Chemistry Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-7234","authenticated-orcid":false,"given":"Jonas","family":"Halfvarson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Gastroenterology Research Group Uppsala University  Uppsala 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