{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:37:45Z","timestamp":1789144665843,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK128567"],"award-info":[{"award-number":["K23DK128567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK131278"],"award-info":[{"award-number":["K23DK131278"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30DK133959"],"award-info":[{"award-number":["L30DK133959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AA031068"],"award-info":[{"award-number":["K23AA031068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011074","name":"Liver Center, University of California, San Francisco","doi-asserted-by":"publisher","award":["P30DK026743"],"award-info":[{"award-number":["P30DK026743"]}],"id":[{"id":"10.13039\/100011074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>The development of acute kidney injury (AKI) in the setting of alcohol\u2010associated hepatitis (AH) portends a poor prognosis. Whether the presence of AH itself drives worse outcomes in patients with cirrhosis and AKI is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of 11 hospital networks of consecutive adult patients admitted in 2019 with cirrhosis and AKI. AKI phenotypes, clinical course, and outcomes were compared between AH and non\u2010AH groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2062 patients were included, of which 303 (15%) had AH, as defined by National Institute on Alcohol Abuse and Alcoholism (NIAAA) criteria. Patients with AH, compared to those without, were younger and had higher Model for End\u2010stage Liver Disease\u2010Sodium (MELD\u2010Na) scores on admission. AKI phenotypes significantly differed between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) with acute tubular necrosis occurring more frequently in patients with AH. Patients with AH reached more severe peak AKI stage, required more renal replacement therapy, and had higher 90\u2010day cumulative incidence of death (45% [95% CI: 39%\u201351%] vs. 38% [95% CI: 35%\u201340%],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). Using no AH as reference, the unadjusted sHR for 90\u2010day mortality was higher for AH (sHR: 1.24 [95% CI: 1.03\u20131.50],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), but was not significant when adjusting for MELD\u2010Na, age and sex. However, in patients with hepatorenal syndrome, AH was an independent predictor of 90\u2010day mortality (sHR: 1.82 [95% CI: 1.16\u20132.86],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hospitalised patients with cirrhosis and AKI presenting with AH had higher 90\u2010day mortality than those without AH, but this may have been driven by higher MELD\u2010Na rather than AH itself. However, in patients with hepatorenal syndrome, AH was an independent predictor of mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18159","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:28:47Z","timestamp":1721089727000},"page":"778-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Outcomes of patients with alcohol\u2010associated hepatitis and acute kidney injury \u2013 Results from the HRS Harmony Consortium"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-111X","authenticated-orcid":false,"given":"Ann T.","family":"Ma","sequence":"first","affiliation":[{"name":"Toronto Centre for Liver Disease University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Allegretti","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-0245","authenticated-orcid":false,"given":"Giuseppe","family":"Cullaro","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California\u2010San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqui","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-5670","authenticated-orcid":false,"given":"Sumeet K.","family":"Asrani","sequence":"additional","affiliation":[{"name":"Baylor University Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Liver Center, Division of Gastroenterology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Przybyszewski","sequence":"additional","affiliation":[{"name":"Liver Center, Division of Gastroenterology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Wilechansky","sequence":"additional","affiliation":[{"name":"Liver Center, Division of Gastroenterology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jevon E.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratima","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Simonetto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Transplant Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasun","family":"Jalal","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Orman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani M.","family":"Wadei","sequence":"additional","affiliation":[{"name":"Department of Transplantation Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelsea A.","family":"St.\u00a0Hillien","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Saly","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-9374","authenticated-orcid":false,"given":"Nneka N.","family":"Ufere","sequence":"additional","affiliation":[{"name":"Liver Center, Division of Gastroenterology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh Anne","family":"Dageforde","sequence":"additional","affiliation":[{"name":"Department of Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Regner","sequence":"additional","affiliation":[{"name":"Division of Nephrology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Belcher","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Internal Medicine Yale University  New Haven Connecticut USA"},{"name":"CT and VA Connecticut Healthcare  West Haven Connecticut 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