{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:55:53Z","timestamp":1789052153762,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The European Society of Paediatric Gastroenterology, Hepatology and Nutrition established guidelines in 2012 for a no\u2010biopsy approach to diagnose coeliac disease in children. This guideline required symptoms suggestive of coeliac disease, positive human leukocyte antigen (HLA) DQ2\/DQ8 haplotypes, tissue transglutaminase type\u20102 immunoglobulin A antibody titre at levels greater than 10 times the upper limit of normal, and positive endomysial immune\u2010globulin A antibody test. An updated 2020 guideline excluded the need for symptoms and positive HLA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the pooled positive predictive value (PPV) of the no\u2010biopsy approach with small bowel biopsy (SBB) data as the reference standard for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Database searches (October 2023) provided data that we combined using a random\u2010effects meta\u2010analysis to provide a pooled PPV, representing the probability that a positive test result means that an individual truly has the condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 23 studies. Study sample sizes totalled 23,769 but only 3007 children had comparative SBB. The proportion of coeliac disease confirmed by the no\u2010biopsy approach and SBB ranged from 79.2% to 100%, with an overall pooled PPV of 97.4% (95% confidence interval 96.0, 98.6). Sensitivity analysis showed higher PPV for the criteria that included HLA (98.5% vs. 96.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both no\u2010biopsy criteria exhibit high PPV when compared to the reference standard. These results provide a consistent message of accuracy and feasibility to inform change and improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18177","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T23:56:32Z","timestamp":1721778992000},"page":"672-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Meta\u2010analysis: High pooled positive predictive value of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition no\u2010biopsy approach for coeliac disease testing in children"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-4959","authenticated-orcid":false,"given":"Angharad","family":"Vernon\u2010Roberts","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Otago Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-4336","authenticated-orcid":false,"given":"Sanjeev","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics King George Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-7386","authenticated-orcid":false,"given":"Andrew S.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Otago Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5690-6560","authenticated-orcid":false,"given":"Shaun S. C.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"},{"name":"Murdoch Children\u2019s Research Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1880320"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/20587384211008709"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000523"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00357"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002056"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010021\u201003974\u20108"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010021\u201001667\u2010y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737\u2010200304000\u201000012"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002424"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.5671"},{"issue":"1505","key":"e_1_2_11_15_1","first-page":"29","article-title":"Diagnostic delays and treatment challenges in children with coeliac disease: The New Zealand Coeliac Health Survey","volume":"132","author":"Coppell KJ","year":"2019","journal-title":"N Z Med J"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001216"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010021\u201006988\u20102"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.202200001-25"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.202100000-28"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010020\u201001062\u20107"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16729"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.023"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2632"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737\u2010199910000\u201000019"},{"key":"e_1_2_11_26_1","unstructured":"Critical Appraisal Skills Programme.CASP diagnostic test study checklist.2018. 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