{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:34:44Z","timestamp":1791520484912,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Apart from direct portal pressure reduction, non\u2010selective beta\u2010blockers (NSBB) modulate inflammatory response, which could be beneficial in patients with acute decompensation (AD). We therefore aimed to evaluate the effect of NSBB on 28\u2010day mortality and markers of systemic inflammation in a propensity score\u2010matched (PSM) cohort of AD patients requiring intensive care unit (ICU) admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were recruited from registry of AD patients requiring ICU admission. Out of total 445 patients, 108 patients on NSBB before admission (NSBB use group) were PSM for age, gender, pre\u2010admission Child\u2013Turcotte\u2013Pugh score and history of previous decompensation to 108 patients not on NSBB (non\u2010NSBB use group) which served as the control group. ICU parameters, markers of systemic inflammation and 28\u2010day mortality were compared by standard statistical tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, no difference was observed in aetiology of cirrhosis, or precipitating event for AD between the groups. Pre\u2010admission creatinine, bilirubin, international normalised ratio and haemoglobin were similar between the groups, whereas pre\u2010admission white cell count (WCC) and neutrophil to lymphocyte ratio (NLR) was lower in NSBB\u2010group. On admission to ICU, NSBB group had lower heart rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), platelets (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), WCC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), NLR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) and C\u2010reactive protein (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Significantly more community acquired bacterial infections (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), renal failure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) and higher grades of acute\u2010on\u2010chronic liver failure (ACLF;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) were observed in non\u2010NSBB group. Significantly lower 28\u2010day (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and 90\u2010day (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) mortality was seen in NSBB group. Univariate and multivariable analysis for 28\u2010day mortality showed that while ACLF at presentation and community acquired bacterial infection were independent negative predictors, prior NSBB use was positive predictors of survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Prior use of NSBB is associated with improved 28\u2010 and 90\u2010day mortality in critically ill cirrhosis patients with AD which is mediated\n                      <jats:italic>probably<\/jats:italic>\n                      by blunting of the inflammatory response.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18188","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T02:17:07Z","timestamp":1722565027000},"page":"907-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Non\u2010selective beta\u2010blocker is associated with reduced mortality in critically ill patients with cirrhosis: A real\u2010world study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-4821","authenticated-orcid":false,"given":"Rahul","family":"Kumar","sequence":"first","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"},{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Duke\u2010 NUS Academic Medical Centre, CGH Campus  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1756-6775","authenticated-orcid":false,"given":"Su","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"},{"name":"Liver Research Center of the First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Mehta","sequence":"additional","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"},{"name":"Roger Williams Institute of Hepatology Foundation for Liver Research 111 Coldharbour Lane, London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica D.","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"},{"name":"Centro Hospital de Tras\u2010os\u2010Montes e Alto Douro, EPE  Vila Real Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana A. F.","family":"Calvao","sequence":"additional","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"},{"name":"Centro Hospital de Tras\u2010os\u2010Montes e Alto Douro, EPE  Vila Real Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Faisal","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banwari","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Centro Hospital de Tras\u2010os\u2010Montes e Alto Douro, EPE  Vila Real Portugal"},{"name":"Intensive Care Unit Royal Free Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-9384","authenticated-orcid":false,"given":"R. P.","family":"Mookerjee","sequence":"additional","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"},{"name":"Department of Hepatology and Gastroenterology Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-6470","authenticated-orcid":false,"given":"Rajiv","family":"Jalan","sequence":"additional","affiliation":[{"name":"Liver Failure Group UCL Institute for Liver and Digestive Health, UCL Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31875\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23775"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010301348"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.018"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15439"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077558710361486"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000767"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15932"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24702"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.045"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010015\u20100378\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.46.1.65"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010014\u20102362\u20106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30534"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010018\u20102156\u20100"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188151"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(77)80135-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28352"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010322712"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1914900"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.048"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.10.024"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.05.011"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12786"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20102980.12480"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14418"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010015\u20109641\u20101"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14037"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra0809139"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex231"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010019\u20102562\u2010y"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2017.06.007"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8026"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.022"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.18188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T07:08:55Z","timestamp":1731827335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.18188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/apt.18188"],"URL":"https:\/\/doi.org\/10.1111\/apt.18188","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}