{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:53:55Z","timestamp":1789448035739,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\u20102628\u2010B\u2010A49\u2010016\u2010MY3"],"award-info":[{"award-number":["NSTC 112\u20102628\u2010B\u2010A49\u2010016\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C\u2010157"],"award-info":[{"award-number":["V113C\u2010157"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The benefits of HCV eradication on distinct recurrence patterns and long\u2010term hepatic outcomes in patients with hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA) remain uncertain. This study aims to assess the impact of HCV eradication on HCC recurrence patterns and long\u2010term hepatic outcomes after RFA and to identify predictors of recurrence in patients achieving sustained virological response (SVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 274 patients receiving RFA for HCV\u2010related HCC, including 73 and 88 patients treated with interferon\u2010based (IFN) and direct\u2010acting antivirals (DAA) therapy, respectively. We analysed factors associated with local tumour progression (LTP), distant recurrence, overall survival, and hepatic decompensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SVR was achieved in 49.3% of patients undergoing IFN therapy and 93.2% of patients undergoing DAA therapy. HCV eradication was not associated with LTP but significantly correlated with reduced risk of distant recurrence (by DAA: hazard ratio (HR)\u2009=\u20090.449, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), overall survival (by IFN: HR\u2009=\u20090.242, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; by DAA: HR\u2009=\u20090.274, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and hepatic decompensation (by IFN: HR\u2009=\u20090.313, <jats:italic>p<\/jats:italic>\u2009=\u20090.004; by DAA: HR\u2009=\u20090.281, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The benefits of achieving SVR in terms of overall survival and hepatic decompensation remained significant in subgroups of patients with and without recurrence. Patients with SVR showed a significant decline in FIB\u20104 score and a higher proportion of ALBI grade improvement. Among SVR patients, the IMbrave050 criteria predicted LTP but not distant recurrence, whereas the FIB\u20104 score after SVR, rather than the baseline FIB\u20104, predicted distant recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCV eradication was associated with a significant reduction in distant recurrence, mortality and hepatic decompensation following RFA in patients with HCV\u2010related HCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18199","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:38:30Z","timestamp":1723095510000},"page":"940-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of <scp>HCV<\/scp> eradication on recurrence pattern and long\u2010term outcomes in patients with <scp>HCV<\/scp>\u2010related hepatocellular carcinoma undergoing radiofrequency ablation"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3531-1413","authenticated-orcid":false,"given":"Kuo\u2010Cheng","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Keelung Hospital, Ministry of Health and Welfare  Keelung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-4682","authenticated-orcid":false,"given":"I\u2010Cheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Ta","family":"Chi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010An","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Radiology Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2010Chi","family":"Chiu","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University  Taipei 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