{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:47:02Z","timestamp":1789588022848,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["NCD\/Adhoc\/123\/2022\u201023"],"award-info":[{"award-number":["NCD\/Adhoc\/123\/2022\u201023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Myokines are the muscle\u2010derived hormones orchestrating muscle and systemic health. Their role in the progression of alcohol\u2010associated liver disease (ALD) remains elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three\u2010hundred\u2010one patients across the spectrum of ALD including fatty liver (FL, <jats:italic>N<\/jats:italic>\u2009=\u200913), compensated cirrhosis (CC, <jats:italic>N<\/jats:italic>\u2009=\u200917), non\u2010acute decompensation (NAD, <jats:italic>N<\/jats:italic>\u2009=\u200995), acute decompensation (AD, <jats:italic>N<\/jats:italic>\u2009=\u200951) and acute\u2010on\u2010chronic liver failure (ACLF, <jats:italic>N<\/jats:italic>\u2009=\u2009125) were recruited between 2021 and 2023. Plasma myostatin, decorin levels, nutritional status, handgrip strength (HGS), systemic inflammation, infection, ammonia, disease course and 30\u2010day mortality were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients aged 48\u2009years (IQR: 38\u201352) and 97.7% of males were enrolled. Myostatin was elevated while decorin was reduced in cirrhosis compared to without cirrhosis, and further in DC compared to CC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A step\u2010wise increase in myostatin and reduction in decorin was observed transitioning from NAD to AD to ACLF (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Myostatin was further increased and decorin was reduced along with the grades and organ failures in AD and ACLF (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, each). Baseline decorin (AUC: 0.797) and its combination with MELD (AUC: 0.814) predicted disease resolution in AD and ACLF. Although, both myostatin (aOR: 18.96) and decorin (aOR: 0.02) could predict mortality, decorin was independent (aOR: 0.04) and additive to MELD (AUC of MELD+<jats:sub>log<\/jats:sub>Decorin\u2009+\u2009<jats:sub>log<\/jats:sub>TLC\u2009+\u2009HE\u2010grade:0.815); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 each. Myostatin increased and decorin reduced with inflammation, hyperammonaemia, malnutrition and HGS in AD and ACLF (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myokines are linked with malnutrition, fibrosis, systemic inflammation, organ failures, disease course and mortality in ALD. Decorin enhances the risk estimation of mortality of MELD in AD and ACLF. Therapeutic modulation of myokines is a potentially disease\u2010modifying target in ALD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18202","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T04:44:45Z","timestamp":1723524285000},"page":"1005-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Myokines are associated with progression, course and mortality in alcohol\u2010associated liver disease"],"prefix":"10.1111","volume":"60","author":[{"given":"Parminder","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Hepatology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4328-0914","authenticated-orcid":false,"given":"Nipun","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Hepatology Post Graduate Institute 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