{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:39:43Z","timestamp":1785267583578,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Non\u2010selective beta\u2010blockers (NSBB) are a well\u2010established treatment in patients with clinically significant portal hypertension. However, their potential role after insertion of a transjugular intrahepatic portosystemic shunt (TIPS) still needs to be determined. Of note, recent studies suggested that favourable anti\u2010inflammatory effects of NSBB might be independent from pressure reduction. This study aimed to evaluate whether NSBB\u2010treatment is associated with amelioration of systemic inflammation (SI), hepatic decompensation and survival after TIPS\u2010insertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective study comprising 305 consecutive patients, we investigated the impact of NSBB\u2010intake at TIPS\u2010placement on periinterventional cirrhosis\u2010associated complications and continued NSBB\u2010treatment after discharge on complications including hepatic decompensation and mortality during 1\u2010year follow\u2010up, employing multivariable competing\u2010risk\u2010analyses. In a prospective cohort including 45 patients, we performed a comprehensive analysis of SI analysing 48 soluble inflammatory markers (SIMs) at baseline plus 3 and 6\u2009months after TIPS\u2010insertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 175 (57.4%) patients received NSBB\u2010therapy prior to TIPS\u2010insertion; upon discharge, this decreased to 131 (22.9%), with 36 (27.5%) discontinuing NSBB within 1\u2010year follow\u2010up. Neither NSBB\u2010therapy at TIPS\u2010insertion nor treatment\u2010continuation after discharge were associated with lower risks for hepatic decompensation, individual cirrhosis\u2010associated complications or mortality neither in the periinterventional period nor during follow\u2010up. Similarly, in the prospective cohort NSBB\u2010intake was not linked to lower levels or a more prominent change of WBC, CRP or any other SIM at any of the investigated time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NSBB\u2010therapy at the time of TIPS\u2010insertion and its (dis\u2010)continuation afterwards seems to have no significant impact on SI, development of hepatic decompensation and survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18204","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T05:10:01Z","timestamp":1724821801000},"page":"1021-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["No value of non\u2010selective beta\u2010blockers after <scp>TIPS<\/scp>\u2010insertion"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-8307","authenticated-orcid":false,"given":"Anja","family":"Tiede","sequence":"first","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology Infectious Diseases and Endocrinology  Hannover Germany"},{"name":"German Center for Infection Research (DZIF) Hannover\u2010Braunschweig  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Stockhoff","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology Infectious Diseases and Endocrinology  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Rieland","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology Infectious Diseases and Endocrinology  Hannover 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