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Ther"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) requires at least one of five cardiometabolic criteria. It is unclear whether these criteria can be used as predictors and treatment targets for complications including liver\u2010related events and major adverse cardiovascular events (MACE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the relationship between cardiometabolic criteria and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nationwide, population\u2010based study of 979,352 patients with MASLD. We investigated relationships between a number of criteria at baseline and liver\u2010related events or MACE risks. In a separate longitudinal analysis, we included patients with five criteria at baseline and investigated the relationship between improving the criteria and the incidence of complications after 1\u2009year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence of MACE, but not liver\u2010related events, increased with increasing baseline cardiometabolic criteria. In the longitudinal study, multivariable analysis using patients with five criteria (no improvement) as the reference, adjusted hazard ratios (95% confidence interval) of MACE in patients with 4, 3, 2, and 0\u20131 criteria (1 to 4\u20135 criteria improvement) were 0.55 (0.52\u20130.58, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), 0.20 (0.17\u20130.22, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), 0.13 (0.11\u20130.16, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and 0.06 (0.02\u20130.3, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), respectively. The risk of MACE decreased as the cardiometabolic criteria improved. There was no significant association between improvement of the criteria and liver\u2010related events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiometabolic criteria can be used as predictors and treatment targets for cardiovascular event risk in MASLD. Developing predictors and therapeutic targets for liver\u2010related events is a future challenge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18205","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:11:42Z","timestamp":1723115502000},"page":"1033-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cardiometabolic criteria as predictors and treatment targets of liver\u2010related events and cardiovascular events in metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-6616","authenticated-orcid":false,"given":"Nobuharu","family":"Tamaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo 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