{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:30:12Z","timestamp":1787160612034,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceutica","doi-asserted-by":"publisher","award":["CNTO1275UCO4008"],"award-info":[{"award-number":["CNTO1275UCO4008"]}],"id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ustekinumab is approved for ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the durability of ustekinumab in patients with UC and its short\u2010term effectiveness, durability and tolerability in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, multicentre study of patients who had received their first ustekinumab dose at least 16\u2009weeks before inclusion. Patients were followed until treatment discontinuation or last visit. Only patients with active disease at the start of ustekinumab treatment were considered in the effectiveness analysis. Patients who stopped ustekinumab before their last visit were considered not to be in subsequent remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 620 patients; 155 (25%) discontinued ustekinumab during follow\u2010up (median 12\u2009months). Rate of discontinuation was 20% per patient\u2010year of follow\u2010up. Anaemia at baseline (hazard ratio, HR 1.5; 95% confidence interval [CI] 1.1\u20132.1), steroids at baseline (HR 1.5; 95% CI 1.06\u20132.08) and more severe clinical activity at baseline (HR 1.5; 95% CI 1.09\u20132.06) were associated with higher risk of discontinuation. At the end of induction, 226 (40%) patients were in steroid\u2010free clinical remission. Moderate\u2013severe vs mild disease activity at baseline (odds ratio [OR] 0.3; 95% CI 0.2\u20130.5), male sex (OR 0.5; 95% CI 0.4\u20130.8), and increased number of previous biologics (OR 0.6; 95% CI 0.6\u20130.8) were associated with lower likelihood of steroid\u2010free clinical remission at week 16. One hundred and seventy\u2010six patients (28%) had at least one adverse event. We observed no negative impact of ustekinumab on extraintestinal manifestations and\/or immune\u2010mediated diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ustekinumab durability in UC was relatively high, and treatment was effective in highly refractory patients. The safety profile was consistent with previous studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18230","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T16:50:05Z","timestamp":1726591805000},"page":"1325-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term benefit of ustekinumab in ulcerative colitis in clinical practice: ULISES study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"first","affiliation":[{"name":"Gastrointestinal Units of Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hermida","sequence":"additional","affiliation":[{"name":"Gastrointestinal Units of Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Acosta","sequence":"additional","affiliation":[{"name":"Gastrointestinal Units of Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7513-0764","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Fern\u00e1ndez\u2010Clotet","sequence":"additional","affiliation":[{"name":"Hospital Clinic of Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and CIBEREHD  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Barreiro\u2010de\u00a0Acosta","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario de Santiago  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Hern\u00e1ndez\u00a0Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Torrec\u00e1rdenas  Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa and Fundaci\u00f3n del Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n) and CIBEREHD  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-8797","authenticated-orcid":false,"given":"Marta Maia","family":"Bosca\u2010Watts","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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