{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:03:59Z","timestamp":1784991839651,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To prevent complications of paediatric ulcerative colitis (UC), it is critical to understand their predictors. The Paediatric Inflammatory Bowel Disease Ahead (PIBD Ahead) program identified the relevant outcomes and their potential predictors. However, external validation of these results in larger cohorts is required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to investigate these outcomes and their predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 743 patients aged under 18\u2009years with UC from the multicentre German\u2010Austrian CEDATA\u2010GPGE registry. We performed Cox regressions, Kaplan\u2013Meier estimator, and receiver operating characteristics curve analyses to analyse predictors of poor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Older age at diagnosis was associated with relapse, hospitalisation, the use of immunomodulators, use of biologics, and therapy escalation. Higher disease activity, as in acute severe colitis in the first 3\u2009months, was significantly associated with further acute severe colitis and the need for biologics. Upper gastrointestinal tract involvement was a risk factor for the need of intravenous corticosteroids and biologics. A faecal calprotectin of &gt;685\u2009\u03bcg\/g was associated with a higher risk of subsequent acute severe colitis with a sensitivity of 79.0% and a specificity of 59.1%. A lower haematocrit at diagnosis was predictive of the use of biologics. Colectomy was rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study validates predictors of poor outcomes in paediatric patients with UC. Our results might help physicians to anticipate poor outcomes and initiate appropriate treatment strategies at an early stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18262","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:44:45Z","timestamp":1726033485000},"page":"1421-1434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predicting complications in paediatric ulcerative colitis: A longitudinal multicentre cohort study"],"prefix":"10.1111","volume":"60","author":[{"given":"Merle","family":"Cla\u00dfen","sequence":"first","affiliation":[{"name":"Department of Paediatrics Erlangen University Medical Centre  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Schiller","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Rostock University Medical Centre  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-5283","authenticated-orcid":false,"given":"Jan","family":"D\u00e4britz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Greifswald University Medical Centre  Greifswald Germany"},{"name":"German Centre for Child and Adolescent Health (DZKJ) Site Greifswald\/Rostock  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CEDATA\u2010GPGE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.07.066"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17544"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306999"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.078"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab228"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.063"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab051"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30340-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00065-0"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1907607"},{"key":"e_1_2_12_12_1","first-page":"121","article-title":"Inflammatory bowel disease in pediatric patients","volume":"112","author":"Buderus S","year":"2015","journal-title":"Dtsch \u00c4rztebl Int"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-023-09639-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx125"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1209-x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03291.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.03.007"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31826ac41a"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.26279"},{"key":"e_1_2_12_20_1","unstructured":"NeuhauserH SchienkiewitzA RosarioA et\u00a0al.Referenzperzentile f\u00fcr anthropometrische Ma\u00dfzahlen und Blutdruck aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS).2013."},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.152689"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad111"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002797"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.12.018"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003730"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848211004841"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14070"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otz031"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.853019"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.996875"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311970"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.68696"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.07.065"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000896"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000741"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx092"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001833"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003291"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002035"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002036"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32592-3"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.08.016"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003899"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003698"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac075"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9101558"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003551"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-023-01972-1"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.09.008"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001941"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001531"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1058415"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22864"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa080"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113522"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001803"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1721-x"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl17236"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad052"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05554-y"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz072"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.039"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.01.051"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab061"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz106"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.18262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T12:50:51Z","timestamp":1729774251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.18262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":64,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/apt.18262"],"URL":"https:\/\/doi.org\/10.1111\/apt.18262","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,10]]},"assertion":[{"value":"2024-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}