{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:36Z","timestamp":1791625776771,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several HCC risk stratification scores were developed; however, none has been prospectively validated. The primary aim is to validate the clinical utility of six HCC risk scores in large prospective study of F3\u20104 patients achieving SVR following DAAs according to EASL guidelines. The secondary aim is to explore whether individualized risk stratification improves detection of HCC at early stages amenable to curative treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included two cohorts: Egyptian Liver Research Institute and Hospital (ELRIAH) cohort of 463 chronic HCV patients with advanced liver disease (F3 and F4) achieved SVR with a follow\u2010up every 6\u2009months according to EASL guidelines using 6 simple HCC risk scores and Tanta cohort of 492 comparable patients where individualized surveillance intervals were tailored based on HCC risk assessments using GES score as follows: low\u2010risk patients were followed yearly, intermediate\u2010risk every 6\u2009months and high\u2010risk every 2\u20133\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All scores, except Watanabe post, successfully stratified patients into low\u2010, intermediate\u2010 and high\u2010risk groups, with log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of 0.001 and Harrell's\n                      <jats:italic>C<\/jats:italic>\n                      ranging from 0.669 to 0.728. Clinical utility of these scores revealed that the highest percentage of patients classified as low risk was 42.5% using the GES, while the lowest was 8.9% using the aMAP. ELRIAH cohort, 25 patients developed HCC with 52% diagnosed at BCLC 0 and A. Tanta cohort, 35 patients developed HCC, with 80% diagnosed at BCLC 0 and A.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individualized risk stratification using HCC risk scores was associated with improved early\u2010stage detection and receipt of curative treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18291","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T22:49:57Z","timestamp":1727131797000},"page":"99-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Individualized\n                    <scp>HCC<\/scp>\n                    surveillance using risk stratification scores in advanced fibrosis and cirrhotic\n                    <scp>HCV<\/scp>\n                    patients who achieved\n                    <scp>SVR<\/scp>\n                    : Prospective study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-8854","authenticated-orcid":false,"given":"Gamal","family":"Shiha","sequence":"first","affiliation":[{"name":"Hepatology and Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine Mansoura University  Mansoura Egypt"},{"name":"Egyptian Liver Research Institute and Hospital (ELRIAH)  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Hassan","sequence":"additional","affiliation":[{"name":"Egyptian Liver Research Institute and Hospital (ELRIAH)  Mansoura Egypt"},{"name":"Higher Institute of Applied Medical Sciences  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Mousa","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department, Faculty of Medicine Mansoura University  Mansoura 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