{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:30Z","timestamp":1791625770825,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anxiety and depression are associated strongly with irritable bowel syndrome (IBS). Dietary therapies are used increasingly in the management of IBS, but the impact of common mental disorders on response to these has not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine whether symptoms compatible with common mental disorders influence response to dietary interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cohort study of adults, with either diarrhoea\u2010predominant or mixed bowel habits, IBS Severity Scoring System [IBS\u2010SSS] score\u2009\u2265\u200975 points. Participants completed the Hospital Anxiety and Depression score (HADS) and attended initially for British Dietary Association advice for IBS. IBS\u2010SSS was re\u2010checked 3\u2009months later to assess response. If primary endpoint (\u2265\u200950 point decrease in IBS\u2010SSS) was not achieved, patients were offered low fermentable oligo\u2010, di\u2010 and monosaccharides and polyol diet and repeated IBS\u2010SSS after another 3\u2009months. Secondary endpoints included of change in IBS\u2010SSS and effect of symptom severity on response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 448 patients took part, average age of 42\u2009years and 79.0% were female. 69.9% of participants had HADS\u2010A scores\u2009\u2265\u20098 and 39.3% with HADS\u2010D scores\u2009\u2265\u20098. Average IBS\u2010SSS score at baseline was 290 (SD 86). No significant difference was noted in achievement of the primary endpoint according to HADS\u2010A scores (53.4% vs. 62.2% by ITT in those with HADS\u2010A\u2009\u2265\u20098 vs. HADS\u2010A\u2009&lt;\u20098,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). Patients with HADS\u2010D\u2009\u2265\u20098 were significantly less likely to achieve the primary endpoint compared with those with HADS\u2010D\u2009&lt;\u20098 (43.8% vs. 64.0% by ITT,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Understanding psychological profile of patients can help predicting their response to IBS dietary interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18337","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T09:19:16Z","timestamp":1728638356000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of\n                    <scp>HADS<\/scp>\n                    Anxiety and Depression Scores on the Efficacy of Dietary Interventions for Irritable Bowel Syndrome"],"prefix":"10.1111","volume":"61","author":[{"given":"Anthony","family":"O'Connor","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Trinity College Dublin Tallaght University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Trinity College Dublin Tallaght University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Neary","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Trinity College Dublin Tallaght University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"White","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Trinity College Dublin Tallaght 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