{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:06:33Z","timestamp":1781658393203,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022ZFJH003"],"award-info":[{"award-number":["2022ZFJH003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early identification of hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF) holds crucial importance in guiding clinical management and reducing mortality. However, existing scoring systems often overlook patient's underlying clinical condition, which significantly impacts prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Use the age\u2010adjusted Charlson comorbidity index (aCCI) to evaluate the patient's complications to develop a more precise model for predicting transplant\u2010free mortality in HBV\u2010ACLF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine hundred and six patients were included for investigation and were segregated into a training cohort and a temporal validation cohort according to the chronological order of admission in a ratio of 7:3. In the training cohort, univariate analysis, logistic regression analysis and LASSO regression analysis were used to construct a prognostic model and it was subsequently validated in a temporal validation cohort and an external validation cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found total bilirubin, neutrophils, international normalised ratio and aCCI exhibited significant associations with 28\u2010day transplant\u2010free mortality and established a novel prognostic model, named aCCI\u2010HBV\u2010ACLF. The model demonstrated strong predictive performance, with area under the receiver operating characteristic curve (ROC) values of 0.859 for 28\u2010day mortality, 0.822 for 90\u2010day mortality. In the temporal validation cohort, aCCI\u2010HBV\u2010ACLF achieved area under the ROC values of 0.869 for 28\u2010day mortality and 0.850 for 90\u2010day mortality. In the external validation cohort, aCCI\u2010HBV\u2010ACLF had area under the ROC values of 0.868 for 28\u2010day mortality and 0.888 for 90\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study proposes a new prognostic model, which achieved excellent predictive ability for 28\u2212\/90\u2010day transplant\u2010free mortality rates among patients with HBV\u2010ACLF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18347","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T06:22:12Z","timestamp":1729923732000},"page":"286-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>aCCI<\/scp>\u2010<scp>HBV<\/scp>\u2010<scp>ACLF<\/scp>: A Novel Predictive Model for Hepatitis B Virus\u2010Related Acute\u2010On\u2010Chronic Liver Failure"],"prefix":"10.1111","volume":"61","author":[{"given":"Xinyi","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiqiong","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjie","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-8729","authenticated-orcid":false,"given":"Haijun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhejiang Provincial People's Hospital &amp; People's Hospital Affiliated of Hangzhou Medical College  Hangzhou City China"},{"name":"National Medical Center for Infectious Diseases  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"National Medical Center for Infectious Diseases  Hangzhou City China"},{"name":"Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University  Suzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1821-1178","authenticated-orcid":false,"given":"Jiong","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"},{"name":"National Medical Center for Infectious Diseases  Hangzhou City China"},{"name":"Zhejiang Key Laboratory for Diagnosis and Treatment of Physic\u2010Chemical and Aging\u2010Related Injuries  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-0593","authenticated-orcid":false,"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"},{"name":"National Medical Center for Infectious Diseases  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-6867","authenticated-orcid":false,"given":"Hongcui","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou City China"},{"name":"National Medical Center for Infectious Diseases  Hangzhou City China"},{"name":"Zhejiang Key Laboratory for Diagnosis and Treatment of Physic\u2010Chemical and Aging\u2010Related Injuries  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization \u201cWorld Hepatitis Summit 2022 Urges Action to Eliminate Viral Hepatitis as Unexplained Hepatitis Cases in Children Rise Globally \u201dJune 7 2022 https:\/\/www.who.int\/news\/item\/07\u201006\u20102022\u2010world\u2010hepatitis\u2010summit\u20102022\u2010urges\u2010action\u2010to\u2010eliminate\u2010viral\u2010hepatitis\u2010as\u2010unexplained\u2010hepatitis\u2010cases\u2010in\u2010children\u2010rise\u2010globally."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.047"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09946-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2534856"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312670"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322161"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"4","article-title":"Acute\u2010On\u2010Chronic Liver Failure: A Global Disease","volume":"71","author":"Martin Schulz J. 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