{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:37:09Z","timestamp":1789141029868,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK114478"],"award-info":[{"award-number":["DK114478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For people diagnosed with ulcerative colitis (UC), racial disparities exist both in access to medications and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the TriNetX database for two population\u2010based retrospective analyses with Black (<jats:italic>n<\/jats:italic>\u2009=\u200922,519) and Asian (<jats:italic>n<\/jats:italic>\u2009=\u20098,626) individuals with UC matched for age, sex, and ethnicity. Outcomes included mortality, medication prescriptions, and clinical encounters at 6\u2009months and 10\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u2009months and 10\u2009years after diagnosis, Black people had increased mortality (2.7% vs. 1.9% and 8.1% vs. 6.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), were prescribed fewer UC\u2010specific therapies (21.3% vs. 26.4% and 30% vs. 36%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), had higher rates of emergency department visits (22.3% vs. 13.6% and 41.2% vs. 31.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and higher hospitalisation rates (30.1% vs. 25.8% and 42.6% vs. 39.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). At 6\u2009months, they had more opioid prescriptions (18.5% vs. 15.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Asian people had lower mortality at 10\u2009years (5.6% vs. 7.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), higher rates of UC\u2010specific medications at 6\u2009months (28.6% vs. 26.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and more hospitalizations (38.8% vs. 27.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 at 6\u2009months and 50% vs. 42.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 at 10\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Black individuals with UC are prescribed fewer disease\u2010specific therapies compared to White individuals and have increased hospitalizations and mortality. Black individuals have higher rates of opioid prescriptions. Opioids have been associated with increased complication rates in inflammatory bowel disease. These trends are not seen in Asian individuals. This reveals critical disparities in the care of Black people with UC with opportunity for targeted interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18405","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T15:58:56Z","timestamp":1732982336000},"page":"513-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Black Race is Associated with Decreased Exposure to Advanced Therapies and Worse Outcomes in Individuals with Ulcerative Colitis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1599-0643","authenticated-orcid":false,"given":"Caya","family":"McFalls","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Chaaban","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Melia","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otac023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.07.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284819827692"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7019a2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2021.01466"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.07.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-022-05483-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.09.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.202"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac124"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.02.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnma.2023.09.009"},{"key":"e_1_2_9_15_1","volume-title":"Health Insurance Coverage by Race and Hispanic Origin: 2021","author":"Breauna Branch D. 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