{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:59:52Z","timestamp":1784829592437,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK034987"],"award-info":[{"award-number":["P30 DK034987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While inflammation is implicated in the development of numerous cancers, whether eosinophilic oesophagitis (EoE) increases the risk of oesophageal cancer (OCa) remains understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess whether adults with EoE were more likely to have subsequent OCa diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study used data from the MarketScan commercial claims database. Cases were 18\u201364\u2009years old with an oesophageal cancer diagnosis (\u2265\u2009two coding instances) who had no previous oesophageal cancer code. Controls were matched 10:1 by age and time in health plan. All cases and controls had at least 2\u2009years of continuous healthcare coverage before the index date. EoE status required \u2265\u2009two coding instances. We used conditional logistic regression modelling to assess the association between EoE and oesophageal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 5562 eligible cases and 55,620 matched controls, median age was 58.8\u2009years and median number of years in health plan was 5.1. The proportions of male cases and controls were 81.3% and 41.4%, respectively. A history of EoE was rare in both cases and controls. Only two oesophageal cancer cases (0.04%) and 44 controls (0.08%) had evidence of an EoE diagnosis (OR 0.46; 95% CI 0.11\u20131.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EoE is not associated with the development of oesophageal cancer in privately insured adults under 65\u2009years old; co\u2010incidence of EoE and oesophageal cancer is extremely rare. Additional studies are needed to confirm these findings and to evaluate whether they hold in older adults or over longer follow\u2010up, and whether EoE might protect against oesophageal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18431","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T12:24:46Z","timestamp":1733315086000},"page":"363-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["No Association Between Eosinophilic Oesophagitis and Oesophageal Cancer in US Adults: A Case\u2013Control Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Natasha","family":"Albaneze","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary C.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-2317","authenticated-orcid":false,"given":"David A.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1101","authenticated-orcid":false,"given":"Evan S.","family":"Dellon","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.067"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/592850"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13537"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1393134"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.08.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox050"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.48101\/ujms.v126.7688"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2023.1086032"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.18431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T06:07:39Z","timestamp":1735279659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.18431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/apt.18431"],"URL":"https:\/\/doi.org\/10.1111\/apt.18431","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"2024-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}