{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:36:18Z","timestamp":1783384578948,"version":"3.54.6"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D deficiency is linked to worse outcomes in patients with chronic liver diseases (CLD). However, data in patients with autoimmune hepatitis (AIH) remain limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to assess the impact of vitamin D deficiency on the outcomes of individuals with AIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study used the TriNetX research network to identify patients with AIH. Patients were matched using propensity score matching and stratified to sufficient vitamin D levels (e.g., 25 (OH) D3\u2009\u2265\u200930\u2009ng\/mL), vitamin D insufficiency (25 (OH) D3: 20\u201329.9\u2009ng\/mL) and vitamin D deficiency (e.g., 25 (OH) D3\u2009&lt;\u200920\u2009ng\/mL). The primary outcome was the all\u2010cause mortality among adult patients with AIH. Secondary outcomes included decompensated liver cirrhosis, acute hepatic failure, liver transplantation (LT), all\u2010cause hospitalizations and all\u2010cause critical care admissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1288 AIH patients with vitamin D deficiency were identified and propensity matched with 1288 patients with normal vitamin D levels. Patients with vitamin D deficiency had significantly increased odds for all\u2010cause mortality compared to those with normal levels (adjusted odds ratio (aOR)\u2009=\u20093.2, 95%CI: 2.3\u20134.48). Patients with vitamin D deficiency were at increased odds of all\u2010cause hospitalizations (aOR\u2009=\u20092.37, 95%CI: 1.97\u20132.84), critical care unit admissions (aOR\u2009=\u20092.8, 95%CI: 2.21\u20133.71), decompensated liver cirrhosis (aOR\u2009=\u20092.74, 95%CI: 2.13\u20133.54), acute hepatic failure (aOR\u2009=\u20093.11, 95%CI: 2.09\u20134.62) and LT (aOR\u2009=\u20093.47, 95%CI: 1.71\u20137.04), as compared to those with normal vitamin D levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This cohort study showed significantly increased odds for all\u2010cause mortality in AIH patients with vitamin D deficiency. Vitamin D deficiency in patients with AIH was associated with increased likelihood of hospitalisation, decompensated liver cirrhosis, acute liver failure and LT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18438","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:18:30Z","timestamp":1733941110000},"page":"682-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective"],"prefix":"10.1111","volume":"61","author":[{"given":"Yassine","family":"Kilani","sequence":"first","affiliation":[{"name":"Department of Medicine NYC Health + Hospitals, Lincoln \u2010 Weill Cornell Medical College Affiliate  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqr","family":"Alsakarneh","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Missouri\u2010Kansas City 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