{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:34:59Z","timestamp":1791560099372,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK13593701A1"],"award-info":[{"award-number":["R01DK13593701A1"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R03DK129631"],"award-info":[{"award-number":["R03DK129631"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although studies have compared on\u2010treatment effectiveness of infliximab and vedolizumab in patients with ulcerative colitis (UC), there has been limited comparison of treatment sequencing and long\u2010term patient\u2010centred outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare infliximab\u2010first and vedolizumab\u2010first strategy in biologic\u2010na\u00efve patients with UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study in biologic\u2010na\u00efve patients with UC who were treated first with either infliximab or vedolizumab between 2015 and 2021 and followed over 30\u2009months following initiation. Primary outcomes were the number of hospitalisations, corticosteroid courses and serious infections with either strategy (regardless of switch to alternative therapies) within 30\u2009months. We matched the groups 1:1 through cardinality matching, and fit logistic and zero\u2010inflated negative binomial models to compare outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 181 patients (94 vedolizumab\u2010first and 87 infliximab\u2010first treatment strategy). Of these, 144 were matched 1:1. There was no significant difference in the incidence of IBD\u2010related hospitalisations (incidence rate ratio [IRR], 1.98 [95% CI, 0.64\u20136.10]), corticosteroid courses (0.66 [0.38\u20131.15]) and serious infections (5.26 [0.62\u201345.45]), with comparable incidence of medication switches to alternative advanced therapies (1.08 [0.42\u20132.81]). At 30\u2009months, there was no difference in proportion of patients in clinical remission (69.4% vs. 76.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.45) and endoscopic remission (55.6% vs. 65.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.36).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with UC, long\u2010term effectiveness and safety outcomes are comparable with infliximab\u2010first and vedolizumab\u2010first treatment strategies at 30\u2009months. This can help to guide selection of treatment strategies in patients with UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18441","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T07:28:46Z","timestamp":1733902126000},"page":"693-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010Term Outcomes of an Infliximab\u2010First Versus Vedolizumab\u2010First Treatment Strategy in Biologic\u2010Na\u00efve Patients With Ulcerative Colitis"],"prefix":"10.1111","volume":"61","author":[{"given":"Austin","family":"Haynesworth","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Hung","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"},{"name":"Division of Gastroenterology, Department of Internal Medicine Yeouido St. Mary's Hospital College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid S.","family":"Boland","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Syal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Xu","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-7269","authenticated-orcid":false,"given":"Siddharth","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"},{"name":"Division of Biomedical Informatics, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00744-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab058"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.07.038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.12.030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.02.032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.07.032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCM.0000000000000231"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3356"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.20555"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Multivariate Imputation by Chained Equations in R","volume":"45","author":"Van Buuren S. 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