{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:19:25Z","timestamp":1790144365438,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acid reflux is a common presentation in primary care leading to a high volume of referrals to endoscopy that are often normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine whether a non\u2010endoscopic capsule sponge biomarker test could triage patients with low\u2010risk reflux symptoms, reduce endoscopy waiting lists and identify Barrett's oesophagus in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with reflux symptoms on NHS endoscopy waiting lists who were offered a capsule sponge (test group) between February 2021 and August 2022 were included in this national multicentre prospective cohort study and compared with eligible patients on the standard endoscopy pathway (counterfactual group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two thousand one hundred seventy patients from 23 hospitals undertook a capsule sponge triage test and submitted follow\u2010up data, of whom 1694 (78%) were discharged without endoscopy and 476 (22%) were referred for endoscopy. In a detailed subgroup analysis 1411\/1549 (92%) attended and successfully swallowed the capsule of whom 307\/1411 (21.8%) required endoscopy. Of 111 patients with positive capsule sponge biomarker results who had endoscopy, 19.8% had Barrett's oesophagus. In comparison, in patients with negative sponge biomarkers who were referred for endoscopy due to ongoing symptoms, none had Barrett's oesophagus (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002). Eighty\u2010two percent surveyed (267\/357) were satisfied with the alternative pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Capsule sponge triage is feasible, safe and acceptable. It substantially reduces the endoscopy burden for routine reflux referrals with a favourable diagnostic yield for Barrett's oesophagus. Longer term follow\u2010up will help to confidently assess the impact of the programme and place of capsule sponge in the diagnostic pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18472","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:15:13Z","timestamp":1736554513000},"page":"876-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Use of a Non\u2010Endoscopic Capsule\u2010Sponge Triage Test for Reflux Symptoms: Results From the\n                    <scp>NHS<\/scp>\n                    England Prospective Real\u2010World Evaluation"],"prefix":"10.1111","volume":"61","author":[{"given":"Vlasios","family":"Gourgiotis","sequence":"first","affiliation":[{"name":"Barts Cancer Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Graham","sequence":"additional","affiliation":[{"name":"NHS England  England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Foerster","sequence":"additional","affiliation":[{"name":"NHS England  England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NHS England Pilot and NHS England Oversight Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Early Cancer Insitute Department of Oncology, University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Harvey","sequence":"additional","affiliation":[{"name":"Bedfordshire Hospitals NHS Foundation Trust  Bedfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-2682","authenticated-orcid":false,"given":"Danielle L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology East and North Hertfordshire NHS Trust  Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102016\u2010313589"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12889\u2010023\u201015272\u2010Z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100086\u2010z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102024\u2010332071"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000287\u2010w"},{"key":"e_1_2_12_8_1","unstructured":"\u201cNHS Long Term Plan Cancer \u201daccessed 8 September 2024 https:\/\/www.longtermplan.nhs.uk\/areas\u2010of\u2010work\/cancer\/."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.C4372"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1001780"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010054258"},{"key":"e_1_2_12_12_1","unstructured":"B.Ghimire R.Landy R.Maroni et\u00a0al. \u201cPredictors of the Experience of a Cytosponge Test: Analysis of Patient Survey Data from the BEST3 Trial \u201dhttps:\/\/doi.org\/10.1186\/s12876\u2010022\u201002630\u20101."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31099\u20100"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(21)00667\u20107"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/HIS.13039"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/DOTE\/DOAD061"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/QJMED\/HCAD093"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/FLGASTRO\u20102022\u2010102288"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2018.07.043"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN\u20102016\u2010013901"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102024\u2010BSG.54"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/CODI.15134"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406223221137501"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.18472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.18472","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.18472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:15:58Z","timestamp":1771326958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.18472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/apt.18472"],"URL":"https:\/\/doi.org\/10.1111\/apt.18472","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]},"assertion":[{"value":"2024-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}