{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:45:40Z","timestamp":1791773140636,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["Grant (5\/4\/3\/8 Gastro)"],"award-info":[{"award-number":["Grant (5\/4\/3\/8 Gastro)"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016724","name":"Postgraduate Institute of Medical Education and Research, Chandigarh","doi-asserted-by":"publisher","award":["intramural grant (RGC\u20106701)"],"award-info":[{"award-number":["intramural grant (RGC\u20106701)"]}],"id":[{"id":"10.13039\/100016724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>We assessed clinical, procoagulant and genetic risk factors and clinical outcomes in dabigatran\u2010treated patients with non\u2010tumoural acute and acute\u2010on\u2010chronic portal vein thrombosis (PVT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a new diagnosis of non\u2010tumoural acute and acute\u2010on\u2010chronic PVT between January 2021 and January 2024 (aged\u2009\u2265\u200918\u2009years) in those without\/with cirrhosis (Child\u2010Pugh (CP)\u2010A\/B\/C\u2009\u2264\u200910) were started on dabigatran and followed and compared with those on vitamin K antagonist (VKA) and untreated individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dabigatran was prescribed in 119 patients with PVT type 1 (61, 51.3%), type 2 (34, 28.6%), type 3 (24, 20.2%); 72 (60.5%) with cirrhosis [CP\u2010A (27, 37.5%), CP\u2010B (43, 59.7%) and CP\u2010C10 (2, 2.8%)]. Procoagulant factors noted were JAK2V617F (10.1%), CALR (2.5%) and factor V Leiden (1.6%) mutations, antiphospholipid syndrome (APS, 15.2%), isolated Protein C (14.3%) and Protein S (16.8%) deficiency. Comparators: 28 patients who declined anticoagulation\/were unable to come for follow\u2010up, and six with CP\u2010C received VKA. Overall recanalization rate (RR) on dabigatran was 56 (47.1%); 25 (21%) complete recanalization, 31 (26%) partial recanalization and 63 (52.9%) stable PVT over median follow\u2010up of 32\u2009months. Patients not anticoagulated had a spontaneous RR in 21.4% (28 patients; <jats:italic>p<\/jats:italic>\u2009=\u20090.005 compared with dabigatran group) and none recanalized on VKA. On multivariable analysis, predictors of recanalization on dabigatran were Factor VIII Antigen level (FVIII:Ag, HR 0.6; 95% CI 0.3\u20130.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.032), non\u2010occlusive PVT (HR 3.5, 95% CI 1.9\u20135.6, <jats:italic>p<\/jats:italic>\u2009=\u20090.025) and acute PVT (HR 2.1; 95% CI 1.5\u20133.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Mortality was 14 (11.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>On dabigatran, 47% of 119 patients achieved portal vein recanalization over 32\u2009months of follow\u2010up which was higher than the spontaneous RR (21.4%) in an untreated cohort. High Factor VIII:Ag was a predictor of non\u2010recanalization. Dabigatran was safe in cirrhosis (CP\u2010A and B) while further work is needed in CP\u2010C.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18474","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T08:11:55Z","timestamp":1735891915000},"page":"971-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Experience With Dabigatran on Rate of Portal Vein Thrombosis Recanalization, Disease Progression and Survival"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-4148","authenticated-orcid":false,"given":"Madhumita","family":"Premkumar","sequence":"first","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Bhujade","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and 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